Combination of hypercholesterolemia and hypertension augments renal function abnormalities

Martin Rodriguez-Porcel, James D. Krier, Amir Lerman, Patrick F. Sheedy, J. Carlos Romero, Claudio Napoli, Lilach O. Lerman

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Hypercholesterolemia and hypertension are both risk factors for end-stage renal disease. This study was designed to examine whether their coexistence augmented impairment in renal function and redox status. Regional renal hemodynamics and function in response to vasoactive challenges with acetylcholine or sodium nitroprusside were quantified by using electron-beam computed tomography in pigs after 12 weeks of either a normal (n=10) or hypercholesterolemic (n= 10) diet, renovascular hypertension (n=7), or combined hypercholesterolemia+hypertension (n=6). The hypercholesterolemic and hypercholesterolemic+hypertensive groups had significantly increased serum cholesterol levels, whereas in the hypertensive and hypercholesterolemic+hypertensive groups, mean arterial pressure was significantly elevated compared with the group fed a normal diet. Basal regional renal perfusion and glomerular filtration rates were similar among the groups. In response to acetylcholine, cortical perfusion increased in normal animals (15.6±4.7%, P=0.002) but not in hypercholesterolemic or hypertensive animals (8.0±7.4% and 8.2±5.9%, respectively: P>0.05). Moreover, in the hypercholesterolemic+hypertensive group, cortical perfusion response was further attenuated (2.5±4.8%, P=0.02) and significantly different from the group fed a normal diet (P

Original languageEnglish
Pages (from-to)774-780
Number of pages7
JournalHypertension
Volume37
Issue number2 II
Publication statusPublished - 2001

Fingerprint

Renal Hypertension
Hypercholesterolemia
Perfusion
Diet
Kidney
Acetylcholine
Hypertension
Renovascular Hypertension
X Ray Computed Tomography
Nitroprusside
Glomerular Filtration Rate
Chronic Kidney Failure
Oxidation-Reduction
Arterial Pressure
Swine
Hemodynamics
Cholesterol
Serum

Keywords

  • Blood flow
  • Cholesterol
  • Hypertension
  • Imaging
  • Oxidative stress
  • Renal

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Rodriguez-Porcel, M., Krier, J. D., Lerman, A., Sheedy, P. F., Romero, J. C., Napoli, C., & Lerman, L. O. (2001). Combination of hypercholesterolemia and hypertension augments renal function abnormalities. Hypertension, 37(2 II), 774-780.

Combination of hypercholesterolemia and hypertension augments renal function abnormalities. / Rodriguez-Porcel, Martin; Krier, James D.; Lerman, Amir; Sheedy, Patrick F.; Romero, J. Carlos; Napoli, Claudio; Lerman, Lilach O.

In: Hypertension, Vol. 37, No. 2 II, 2001, p. 774-780.

Research output: Contribution to journalArticle

Rodriguez-Porcel, M, Krier, JD, Lerman, A, Sheedy, PF, Romero, JC, Napoli, C & Lerman, LO 2001, 'Combination of hypercholesterolemia and hypertension augments renal function abnormalities', Hypertension, vol. 37, no. 2 II, pp. 774-780.
Rodriguez-Porcel M, Krier JD, Lerman A, Sheedy PF, Romero JC, Napoli C et al. Combination of hypercholesterolemia and hypertension augments renal function abnormalities. Hypertension. 2001;37(2 II):774-780.
Rodriguez-Porcel, Martin ; Krier, James D. ; Lerman, Amir ; Sheedy, Patrick F. ; Romero, J. Carlos ; Napoli, Claudio ; Lerman, Lilach O. / Combination of hypercholesterolemia and hypertension augments renal function abnormalities. In: Hypertension. 2001 ; Vol. 37, No. 2 II. pp. 774-780.
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