Abstract
Hypercholesterolemia and hypertension are both risk factors for end-stage renal disease. This study was designed to examine whether their coexistence augmented impairment in renal function and redox status. Regional renal hemodynamics and function in response to vasoactive challenges with acetylcholine or sodium nitroprusside were quantified by using electron-beam computed tomography in pigs after 12 weeks of either a normal (n=10) or hypercholesterolemic (n= 10) diet, renovascular hypertension (n=7), or combined hypercholesterolemia+hypertension (n=6). The hypercholesterolemic and hypercholesterolemic+hypertensive groups had significantly increased serum cholesterol levels, whereas in the hypertensive and hypercholesterolemic+hypertensive groups, mean arterial pressure was significantly elevated compared with the group fed a normal diet. Basal regional renal perfusion and glomerular filtration rates were similar among the groups. In response to acetylcholine, cortical perfusion increased in normal animals (15.6±4.7%, P=0.002) but not in hypercholesterolemic or hypertensive animals (8.0±7.4% and 8.2±5.9%, respectively: P>0.05). Moreover, in the hypercholesterolemic+hypertensive group, cortical perfusion response was further attenuated (2.5±4.8%, P=0.02) and significantly different from the group fed a normal diet (P
| Original language | English |
|---|---|
| Pages (from-to) | 774-780 |
| Number of pages | 7 |
| Journal | Hypertension |
| Volume | 37 |
| Issue number | 2 II |
| Publication status | Published - 2001 |
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Keywords
- Blood flow
- Cholesterol
- Hypertension
- Imaging
- Oxidative stress
- Renal
ASJC Scopus subject areas
- Internal Medicine
Cite this
Combination of hypercholesterolemia and hypertension augments renal function abnormalities. / Rodriguez-Porcel, Martin; Krier, James D.; Lerman, Amir; Sheedy, Patrick F.; Romero, J. Carlos; Napoli, Claudio; Lerman, Lilach O.
In: Hypertension, Vol. 37, No. 2 II, 2001, p. 774-780.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combination of hypercholesterolemia and hypertension augments renal function abnormalities
AU - Rodriguez-Porcel, Martin
AU - Krier, James D.
AU - Lerman, Amir
AU - Sheedy, Patrick F.
AU - Romero, J. Carlos
AU - Napoli, Claudio
AU - Lerman, Lilach O.
PY - 2001
Y1 - 2001
N2 - Hypercholesterolemia and hypertension are both risk factors for end-stage renal disease. This study was designed to examine whether their coexistence augmented impairment in renal function and redox status. Regional renal hemodynamics and function in response to vasoactive challenges with acetylcholine or sodium nitroprusside were quantified by using electron-beam computed tomography in pigs after 12 weeks of either a normal (n=10) or hypercholesterolemic (n= 10) diet, renovascular hypertension (n=7), or combined hypercholesterolemia+hypertension (n=6). The hypercholesterolemic and hypercholesterolemic+hypertensive groups had significantly increased serum cholesterol levels, whereas in the hypertensive and hypercholesterolemic+hypertensive groups, mean arterial pressure was significantly elevated compared with the group fed a normal diet. Basal regional renal perfusion and glomerular filtration rates were similar among the groups. In response to acetylcholine, cortical perfusion increased in normal animals (15.6±4.7%, P=0.002) but not in hypercholesterolemic or hypertensive animals (8.0±7.4% and 8.2±5.9%, respectively: P>0.05). Moreover, in the hypercholesterolemic+hypertensive group, cortical perfusion response was further attenuated (2.5±4.8%, P=0.02) and significantly different from the group fed a normal diet (P
AB - Hypercholesterolemia and hypertension are both risk factors for end-stage renal disease. This study was designed to examine whether their coexistence augmented impairment in renal function and redox status. Regional renal hemodynamics and function in response to vasoactive challenges with acetylcholine or sodium nitroprusside were quantified by using electron-beam computed tomography in pigs after 12 weeks of either a normal (n=10) or hypercholesterolemic (n= 10) diet, renovascular hypertension (n=7), or combined hypercholesterolemia+hypertension (n=6). The hypercholesterolemic and hypercholesterolemic+hypertensive groups had significantly increased serum cholesterol levels, whereas in the hypertensive and hypercholesterolemic+hypertensive groups, mean arterial pressure was significantly elevated compared with the group fed a normal diet. Basal regional renal perfusion and glomerular filtration rates were similar among the groups. In response to acetylcholine, cortical perfusion increased in normal animals (15.6±4.7%, P=0.002) but not in hypercholesterolemic or hypertensive animals (8.0±7.4% and 8.2±5.9%, respectively: P>0.05). Moreover, in the hypercholesterolemic+hypertensive group, cortical perfusion response was further attenuated (2.5±4.8%, P=0.02) and significantly different from the group fed a normal diet (P
KW - Blood flow
KW - Cholesterol
KW - Hypertension
KW - Imaging
KW - Oxidative stress
KW - Renal
UR - http://www.scopus.com/inward/record.url?scp=0035092991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035092991&partnerID=8YFLogxK
M3 - Article
C2 - 11230372
AN - SCOPUS:0035092991
VL - 37
SP - 774
EP - 780
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2 II
ER -