TY - JOUR
T1 - Combination of lisinopril and nifedipine GITS increases blood pressure control compared with single drugs in essential hypertensive patients
AU - Taddei, Stefano
AU - Omboni, Stefano
AU - Ghiadoni, Lorenzo
AU - Caiazza, Alberto
AU - Fogari, Roberto
AU - Innocenti, Pierfranco
AU - Porcellati, Carlo
AU - Giovannetti, Roberto
AU - Corradi, Luca
AU - Mancia, Giuseppe
AU - Salvetti, Antonio
PY - 2003/4/1
Y1 - 2003/4/1
N2 - The present study was designed to evaluate the effect of combination therapy using the angiotensin-converting enzyme-inhibitor lisinopril and the dihydropyridine calcium antagonist nifedipine GITS on the degree and homogeneity of 24-hour blood pressure reduction in essential hypertensive patients. After a 4-week placebo run-in period, 51 patients (mean age, 54.4 ± 9.4 years) with essential hypertension and clinic diastolic blood pressure between 105 and 115 mm Hg were randomized to 4-week treatment with lisinopril (20 mg), nifedipine GITS (30 mg), or their combination according to a multicenter, randomized, double-blind, crossover study. Trough clinic blood pressure and 24-hour ambulatory blood pressure were measured at the end of the run-in period and after 4 weeks of treatment. In addition to clinic and 24-hour average blood pressure reduction, the trough-to-peak ratio and the smoothness index, a new measure for the homogeneity of blood pressure reduction, were also calculated. Although both lisinopril and nifedipine GITS produced a significant reduction in clinic and 24-hour average blood pressure values, the reduction obtained with the combination was significantly (P
AB - The present study was designed to evaluate the effect of combination therapy using the angiotensin-converting enzyme-inhibitor lisinopril and the dihydropyridine calcium antagonist nifedipine GITS on the degree and homogeneity of 24-hour blood pressure reduction in essential hypertensive patients. After a 4-week placebo run-in period, 51 patients (mean age, 54.4 ± 9.4 years) with essential hypertension and clinic diastolic blood pressure between 105 and 115 mm Hg were randomized to 4-week treatment with lisinopril (20 mg), nifedipine GITS (30 mg), or their combination according to a multicenter, randomized, double-blind, crossover study. Trough clinic blood pressure and 24-hour ambulatory blood pressure were measured at the end of the run-in period and after 4 weeks of treatment. In addition to clinic and 24-hour average blood pressure reduction, the trough-to-peak ratio and the smoothness index, a new measure for the homogeneity of blood pressure reduction, were also calculated. Although both lisinopril and nifedipine GITS produced a significant reduction in clinic and 24-hour average blood pressure values, the reduction obtained with the combination was significantly (P
KW - Angiotensin
KW - Blood pressure variability
KW - Calcium antagonists
KW - Converting enzyme inhibitors
KW - Hypertension
KW - Trough-to-peak ratio
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U2 - 10.1097/00005344-200304000-00010
DO - 10.1097/00005344-200304000-00010
M3 - Article
C2 - 12658059
AN - SCOPUS:0037379857
VL - 41
SP - 579
EP - 585
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 4
ER -