Combination of lisinopril and nifedipine GITS increases blood pressure control compared with single drugs in essential hypertensive patients

Stefano Taddei, Stefano Omboni, Lorenzo Ghiadoni, Alberto Caiazza, Roberto Fogari, Pierfranco Innocenti, Carlo Porcellati, Roberto Giovannetti, Luca Corradi, Giuseppe Mancia, Antonio Salvetti

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was designed to evaluate the effect of combination therapy using the angiotensin-converting enzyme-inhibitor lisinopril and the dihydropyridine calcium antagonist nifedipine GITS on the degree and homogeneity of 24-hour blood pressure reduction in essential hypertensive patients. After a 4-week placebo run-in period, 51 patients (mean age, 54.4 ± 9.4 years) with essential hypertension and clinic diastolic blood pressure between 105 and 115 mm Hg were randomized to 4-week treatment with lisinopril (20 mg), nifedipine GITS (30 mg), or their combination according to a multicenter, randomized, double-blind, crossover study. Trough clinic blood pressure and 24-hour ambulatory blood pressure were measured at the end of the run-in period and after 4 weeks of treatment. In addition to clinic and 24-hour average blood pressure reduction, the trough-to-peak ratio and the smoothness index, a new measure for the homogeneity of blood pressure reduction, were also calculated. Although both lisinopril and nifedipine GITS produced a significant reduction in clinic and 24-hour average blood pressure values, the reduction obtained with the combination was significantly (P

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalJournal of Cardiovascular Pharmacology
Volume41
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

Keywords

  • Angiotensin
  • Blood pressure variability
  • Calcium antagonists
  • Converting enzyme inhibitors
  • Hypertension
  • Trough-to-peak ratio

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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