Combination of novel systemic agents and radiotherapy for solid tumors – part I: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment efficacy

Stefano Arcangeli, Barbara Alicia Jereczek-Fossa, Filippo Alongi, Cynthia Aristei, Carlotta Becherini, Liliana Belgioia, Michela Buglione, Luciana Caravatta, Rolando Maria D’Angelillo, Andrea Riccardo Filippi, Michele Fiore, Domenico Genovesi, Carlo Greco, Lorenzo Livi, Stefano Maria Magrini, Giulia Marvaso, Rosario Mazzola, Icro Meattini, Anna Merlotti, Isabella PalumboStefano Pergolizzi, Sara Ramella, Umberto Ricardi, Elvio Russi, Marco Trovò, Alessandro Sindoni, Vincenzo Valentini, Renzo Corvò

Research output: Contribution to journalArticle

Abstract

Over the past century, technologic advances have promoted the evolution of radiation therapy into a precise treatment modality allowing for the maximal administration of dose to tumors while sparing normal tissues. In parallel with this technological maturation, the rapid expansion in understanding the basic biology and heterogeneity of cancer has led to the development of several compounds that target specific pathways. Many of them are in advanced steps of clinical development for combination treatments with radiotherapy, and can be incorporated into radiation oncology practice for a personalized approach to maximize the therapeutic gain. This review describes the rationale for combining novel agents with radiation, and provides an overview of the current landscape focused on treatment efficacy.
Original languageEnglish
JournalCritical Reviews in Oncology/Hematology
DOIs
Publication statusPublished - 2018

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    Arcangeli, S., Jereczek-Fossa, B. A., Alongi, F., Aristei, C., Becherini, C., Belgioia, L., Buglione, M., Caravatta, L., D’Angelillo, R. M., Filippi, A. R., Fiore, M., Genovesi, D., Greco, C., Livi, L., Magrini, S. M., Marvaso, G., Mazzola, R., Meattini, I., Merlotti, A., ... Corvò, R. (2018). Combination of novel systemic agents and radiotherapy for solid tumors – part I: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment efficacy. Critical Reviews in Oncology/Hematology. https://doi.org/10.1016/j.critrevonc.2018.11.005