Abstract
Original language | English |
---|---|
Pages (from-to) | 87-103 |
Number of pages | 17 |
Journal | Crit. Rev. Oncol. Hematol. |
Volume | 134 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- abiraterone
- anastrozole
- antineoplastic agent
- apalutamide
- bevacizumab
- capecitabine
- cetuximab
- cisplatin
- docetaxel
- enzalutamide
- erlotinib
- everolimus
- exemestane
- gemcitabine
- imatinib
- letrozole
- nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor
- oxaliplatin
- paclitaxel
- panitumumab
- pertuzumab
- sonidegib
- sorafenib
- sunitinib
- temozolomide
- trastuzumab
- unindexed drug
- veliparib
- vemurafenib
- vismodegib
- radiosensitizing agent
- basal cell carcinoma
- brain metastasis
- breast cancer
- cancer combination chemotherapy
- cancer control
- cancer radiotherapy
- cancer survival
- carcinomatous peritonitis
- clinical effectiveness
- digestive system cancer
- drug efficacy
- drug safety
- esophageal adenocarcinoma
- gastrointestinal stromal tumor
- glioblastoma
- glioma
- head and neck squamous cell carcinoma
- human
- human epidermal growth factor receptor 2 negative breast cancer
- human epidermal growth factor receptor 2 positive breast cancer
- kidney cancer
- kidney metastasis
- melanoma
- metastatic breast cancer
- metastatic colorectal cancer
- muscle invasive bladder cancer
- non small cell lung cancer
- nonhuman
- pancreas cancer
- pancreas islet cell tumor
- phase 2 clinical trial (topic)
- phase 3 clinical trial (topic)
- prostate cancer
- rectum cancer
- renal cell carcinoma
- Review
- solid malignant neoplasm
- treatment failure
- chemoradiotherapy
- Italy
- neoplasm
- treatment outcome
- Chemoradiotherapy
- Humans
- Neoplasms
- Radiation-Sensitizing Agents
- Treatment Outcome
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Combination of novel systemic agents and radiotherapy for solid tumors – part I: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment efficacy : Critical Reviews in Oncology/Hematology. / Arcangeli, S.; Jereczek-Fossa, B.A.; Alongi, F.; Aristei, C.; Becherini, C.; Belgioia, L.; Buglione, M.; Caravatta, L.; D'Angelillo, R.M.; Filippi, A.R.; Fiore, M.; Genovesi, D.; Greco, C.; Livi, L.; Magrini, S.M.; Marvaso, G.; Mazzola, R.; Meattini, I.; Merlotti, A.; Palumbo, I.; Pergolizzi, S.; Ramella, S.; Ricardi, U.; Russi, E.; Trovò, M.; Sindoni, A.; Valentini, V.; Corvò, R.
In: Crit. Rev. Oncol. Hematol., Vol. 134, 2019, p. 87-103.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Combination of novel systemic agents and radiotherapy for solid tumors – part I: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment efficacy
T2 - Critical Reviews in Oncology/Hematology
AU - Arcangeli, S.
AU - Jereczek-Fossa, B.A.
AU - Alongi, F.
AU - Aristei, C.
AU - Becherini, C.
AU - Belgioia, L.
AU - Buglione, M.
AU - Caravatta, L.
AU - D'Angelillo, R.M.
AU - Filippi, A.R.
AU - Fiore, M.
AU - Genovesi, D.
AU - Greco, C.
AU - Livi, L.
AU - Magrini, S.M.
AU - Marvaso, G.
AU - Mazzola, R.
AU - Meattini, I.
AU - Merlotti, A.
AU - Palumbo, I.
AU - Pergolizzi, S.
AU - Ramella, S.
AU - Ricardi, U.
AU - Russi, E.
AU - Trovò, M.
AU - Sindoni, A.
AU - Valentini, V.
AU - Corvò, R.
N1 - Export Date: 25 February 2020 CODEN: CCRHE Correspondence Address: Arcangeli, S.; Department of Radiation Oncology, Policlinico S. Gerardo and University of Milan “Bicocca”, Via Pergolesi 33, Monza (MB) – Italy, Italy; email: stefano.arcangeli@yahoo.it Chemicals/CAS: abiraterone, 154229-19-3; anastrozole, 120511-73-1; apalutamide, 956104-40-8; bevacizumab, 216974-75-3, 1438851-35-4; capecitabine, 154361-50-9; cetuximab, 205923-56-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; docetaxel, 114977-28-5; enzalutamide, 915087-33-1; erlotinib, 183319-69-9, 183321-74-6; everolimus, 159351-69-6; exemestane, 107868-30-4; gemcitabine, 103882-84-4; imatinib, 152459-95-5, 220127-57-1; letrozole, 112809-51-5; oxaliplatin, 61825-94-3; paclitaxel, 33069-62-4; panitumumab, 339177-26-3; sonidegib, 956697-53-3, 1218778-77-8; sorafenib, 284461-73-0; sunitinib, 341031-54-7, 557795-19-4; temozolomide, 85622-93-1; trastuzumab, 180288-69-1, 1446410-98-5; veliparib, 912444-00-9; vemurafenib, 918504-65-1; vismodegib, 879085-55-9; Radiation-Sensitizing Agents References: Ahmed, K.A., Stallworth, D.G., Kim, Y., Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy (2016) Ann. 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PY - 2019
Y1 - 2019
N2 - Over the past century, technologic advances have promoted the evolution of radiation therapy into a precise treatment modality allowing for the maximal administration of dose to tumors while sparing normal tissues. In parallel with this technological maturation, the rapid expansion in understanding the basic biology and heterogeneity of cancer has led to the development of several compounds that target specific pathways. Many of them are in advanced steps of clinical development for combination treatments with radiotherapy, and can be incorporated into radiation oncology practice for a personalized approach to maximize the therapeutic gain. This review describes the rationale for combining novel agents with radiation, and provides an overview of the current landscape focused on treatment efficacy. © 2018 Elsevier B.V.
AB - Over the past century, technologic advances have promoted the evolution of radiation therapy into a precise treatment modality allowing for the maximal administration of dose to tumors while sparing normal tissues. In parallel with this technological maturation, the rapid expansion in understanding the basic biology and heterogeneity of cancer has led to the development of several compounds that target specific pathways. Many of them are in advanced steps of clinical development for combination treatments with radiotherapy, and can be incorporated into radiation oncology practice for a personalized approach to maximize the therapeutic gain. This review describes the rationale for combining novel agents with radiation, and provides an overview of the current landscape focused on treatment efficacy. © 2018 Elsevier B.V.
KW - abiraterone
KW - anastrozole
KW - antineoplastic agent
KW - apalutamide
KW - bevacizumab
KW - capecitabine
KW - cetuximab
KW - cisplatin
KW - docetaxel
KW - enzalutamide
KW - erlotinib
KW - everolimus
KW - exemestane
KW - gemcitabine
KW - imatinib
KW - letrozole
KW - nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor
KW - oxaliplatin
KW - paclitaxel
KW - panitumumab
KW - pertuzumab
KW - sonidegib
KW - sorafenib
KW - sunitinib
KW - temozolomide
KW - trastuzumab
KW - unindexed drug
KW - veliparib
KW - vemurafenib
KW - vismodegib
KW - radiosensitizing agent
KW - basal cell carcinoma
KW - brain metastasis
KW - breast cancer
KW - cancer combination chemotherapy
KW - cancer control
KW - cancer radiotherapy
KW - cancer survival
KW - carcinomatous peritonitis
KW - clinical effectiveness
KW - digestive system cancer
KW - drug efficacy
KW - drug safety
KW - esophageal adenocarcinoma
KW - gastrointestinal stromal tumor
KW - glioblastoma
KW - glioma
KW - head and neck squamous cell carcinoma
KW - human
KW - human epidermal growth factor receptor 2 negative breast cancer
KW - human epidermal growth factor receptor 2 positive breast cancer
KW - kidney cancer
KW - kidney metastasis
KW - melanoma
KW - metastatic breast cancer
KW - metastatic colorectal cancer
KW - muscle invasive bladder cancer
KW - non small cell lung cancer
KW - nonhuman
KW - pancreas cancer
KW - pancreas islet cell tumor
KW - phase 2 clinical trial (topic)
KW - phase 3 clinical trial (topic)
KW - prostate cancer
KW - rectum cancer
KW - renal cell carcinoma
KW - Review
KW - solid malignant neoplasm
KW - treatment failure
KW - chemoradiotherapy
KW - Italy
KW - neoplasm
KW - treatment outcome
KW - Chemoradiotherapy
KW - Humans
KW - Neoplasms
KW - Radiation-Sensitizing Agents
KW - Treatment Outcome
U2 - 10.1016/j.critrevonc.2018.11.005
DO - 10.1016/j.critrevonc.2018.11.005
M3 - Article
VL - 134
SP - 87
EP - 103
JO - Crit. Rev. Oncol. Hematol.
JF - Crit. Rev. Oncol. Hematol.
SN - 1879-0461
ER -