Combination of novel systemic agents and radiotherapy for solid tumors – Part II: An AIRO (Italian association of radiotherapy and clinical oncology) overview focused on treatment toxicity: Critical Reviews in Oncology/Hematology

S. Arcangeli, B.A. Jereczek-Fossa, F. Alongi, C. Aristei, C. Becherini, L. Belgioia, M. Buglione, L. Caravatta, R.M. D'Angelillo, A.R. Filippi, M. Fiore, D. Genovesi, C. Greco, L. Livi, S.M. Magrini, G. Marvaso, R. Mazzola, I. Meattini, A. Merlotti, I. PalumboS. Pergolizzi, S. Ramella, U. Ricardi, E. Russi, M. Trovò, A. Sindoni, V. Valentini, R. Corvò

Research output: Contribution to journalArticle


Clinical development and use of novel systemic agents in combination with radiotherapy (RT) is at nowadays most advanced in the field of treatment of solid tumors. Although for many of these substances preclinical studies provide sufficient evidences on their principal capability to enhance radiation effects, the majority of them have not been investigated in even phase I clinical trials for safety in the context of RT. In clinical practice, unexpected acute and late side effects may emerge especially in combination with RT. As a matter of fact, despite combined modality treatment holds potential for enhancing the therapeutic ratio, some concerns are raised from the lack of high-quality clinical data to guide the care of patients who are treated with novel compounds in conjunction with RT. The aim of this review is to provide, from a radio-oncological point of view, an overview of the most advanced combined treatment concepts for solid tumors focusing on treatment toxicity. © 2018 Elsevier B.V.
Original languageEnglish
Pages (from-to)104-119
Number of pages16
JournalCrit. Rev. Oncol. Hematol.
Publication statusPublished - 2019



  • Radiotherapy
  • Systemic compounds
  • Toxicity
  • abiraterone
  • afatinib
  • antineoplastic agent
  • apalutamide
  • bevacizumab
  • cetuximab
  • cytotoxic T lymphocyte antigen 4 antagonist
  • dabrafenib
  • darolutamide
  • enzalutamide
  • erlotinib
  • everolimus
  • galeterone
  • gefitinib
  • nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor
  • orteronel
  • panitumumab
  • pertuzumab
  • programmed death 1 ligand 1 antagonist
  • programmed death 1 receptor antagonist
  • seviteronel
  • sonidegib
  • sorafenib
  • sunitinib
  • trastuzumab
  • unclassified drug
  • vemurafenib
  • vismodegib
  • radiosensitizing agent
  • cancer radiotherapy
  • cancer survival
  • clinical effectiveness
  • clinical outcome
  • clinical trial (topic)
  • drug effect
  • drug efficacy
  • drug response
  • human
  • quality of life
  • radiation dose
  • Review
  • solid malignant neoplasm
  • survival rate
  • treatment response
  • chemoradiotherapy
  • Italy
  • neoplasm
  • treatment outcome
  • Chemoradiotherapy
  • Humans
  • Neoplasms
  • Radiation-Sensitizing Agents
  • Treatment Outcome

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