Combination therapy with amantadine and interferon in naïve patients with chronic hepatitis C: Meta-analysis of individual patient data from six clinical trials

Alessandra Mangia, Gioacchino Leandro, Beat Helbling, Eberhard L. Renner, Marco Tabone, Laura Sidoli, Simona Caronia, Graham R. Foster, Stephan Zeuzem, Thomas Berg, Vito Di Marco, Nicolina Cino, Angelo Andriulli

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: In chronic hepatitis C, clinical trials evaluating the efficacy of amantadine (AMA) and interferon (INF) compared to INF monotherapy, have produced conflicting results. We performed a meta-analysis of the individual patient's data from previous studies. Methods: Nine hundred and seventy-two patients from six European centres were evaluated by means of individual patient meta-analysis, using mixed models with centres and the centre-treatment interaction fitted as random variables. Results: At the end of therapy, virological responses were 38.5% (95% CI 34.1-42.8) after INF and AMA, and 29.5% (95% CI 25.5-33.6) after INF alone (P=0.003). Sustained response occurred in 111 (23.1%; 95% CI 19.3-20.2) and 85 patients (17.3%; 95% CI 14.0-20.7), respectively (P=0.03). Even accounting for the centre effect, therapy with AMA and INF was more effective than IFN alone (P=0.029). When genotypes and viraemia levels were combined, the response rate after combination therapy doubled that observed with IFN alone in all subgroups, except those with low viraemia and genotypes 2 or 3. Conclusions: In chronic hepatitis C, therapy with AMA and INF is effective and may be an alternative to INF and ribavirin in patients who cannot tolerate ribavirin.

Original languageEnglish
Pages (from-to)478-483
Number of pages6
JournalJournal of Hepatology
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • Amantadine
  • Chronic hepatitis C
  • Interferon
  • Meta-analysis
  • Randomized clinical trials
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology

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