Combinations of apoptosis and cell-cycle control biomarkers predict the outcome of human melanoma

Franca Piras, Maria Teresa Perra, Daniela Murtas, Luigi Minerba, Carlo Floris, Cristina Maxia, Paolo Demurtas, Jorge Ugalde, Domenico Ribatti, Paola Sirigu

Research output: Contribution to journalArticle

Abstract

The deregulation of apoptosis is characteristic of human carcinogenesis. Survivin, an inhibitor of apoptosis, p53 and p16, two tumour suppressor proteins involved in cell cycle control, play a central role in apoptosis. The aim of this study was to investigate, in primary cutaneous melanoma from 68 patients, the expression of survivin with respect to p53 or p16; the association of these proteins, alone or in combination with clinicopathological features; and, most importantly, to elucidate the role of these markers in predicting survival. The level of survivin expression was significantly higher in the p53 positive group of melanomas compared with the p53 negative one, suggesting a cooperative effect in favouring the progression of melanoma, while no correlation was found between survivin and p16. Moreover, the altered expression of nuclear survivin, p53 and p16 were all associated with poor survival, as demonstrated by univariate analysis. However, these biomarkers have been shown to have superior predictive value when studied in combination (P

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalOncology Reports
Volume20
Issue number2
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Melanoma
  • p16
  • p53
  • Survivin
  • Tumour progression

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Piras, F., Perra, M. T., Murtas, D., Minerba, L., Floris, C., Maxia, C., Demurtas, P., Ugalde, J., Ribatti, D., & Sirigu, P. (2008). Combinations of apoptosis and cell-cycle control biomarkers predict the outcome of human melanoma. Oncology Reports, 20(2), 271-277. https://doi.org/10.3892/or_00000003