Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso; Francesco Maria Calabrese; Achille Iolascon; Erling Mellerup

doi:10.1016/j.cancergen.2014.02.004

Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso, Francesco Maria Calabrese, Achille Iolascon, Erling Mellerup

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P

Original language	English
Pages (from-to)	94-97
Number of pages	4
Journal	Cancer genetics
Volume	207
Issue number	3
DOIs	https://doi.org/10.1016/j.cancergen.2014.02.004
Publication status	Published - 2014

Keywords

Combinations
Data mining
Neuroblastoma
SNPs

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

Access to Document

10.1016/j.cancergen.2014.02.004

Cite this

@article{5120cca40de24869bcd7610c9a2939f0,

title = "Combinations of genetic data in a study of neuroblastoma risk genotypes",

abstract = "Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P",

keywords = "Combinations, Data mining, Neuroblastoma, SNPs",

author = "Mario Capasso and Calabrese, {Francesco Maria} and Achille Iolascon and Erling Mellerup",

year = "2014",

doi = "10.1016/j.cancergen.2014.02.004",

language = "English",

volume = "207",

pages = "94--97",

journal = "Cancer genetics",

issn = "2210-7762",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Combinations of genetic data in a study of neuroblastoma risk genotypes

AU - Capasso, Mario

AU - Calabrese, Francesco Maria

AU - Iolascon, Achille

AU - Mellerup, Erling

PY - 2014

Y1 - 2014

N2 - Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P

AB - Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P

KW - Combinations

KW - Data mining

KW - Neuroblastoma

KW - SNPs

UR - http://www.scopus.com/inward/record.url?scp=84899060890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899060890&partnerID=8YFLogxK

U2 - 10.1016/j.cancergen.2014.02.004

DO - 10.1016/j.cancergen.2014.02.004

M3 - Article

C2 - 24726319

AN - SCOPUS:84899060890

VL - 207

SP - 94

EP - 97

JO - Cancer genetics

JF - Cancer genetics

SN - 2210-7762

IS - 3

ER -

Combinations of genetic data in a study of neuroblastoma risk genotypes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this