Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso, Francesco Maria Calabrese, Achille Iolascon, Erling Mellerup

Research output: Contribution to journalArticlepeer-review

Abstract

Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalCancer genetics
Volume207
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Combinations
  • Data mining
  • Neuroblastoma
  • SNPs

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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