Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso; Francesco Maria Calabrese; Achille Iolascon; Erling Mellerup

doi:10.1016/j.cancergen.2014.02.004

Combinations of genetic data in a study of neuroblastoma risk genotypes

Mario Capasso, Francesco Maria Calabrese, Achille Iolascon, Erling Mellerup

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P

Original language	English
Pages (from-to)	94-97
Number of pages	4
Journal	Cancer genetics
Volume	207
Issue number	3
DOIs	https://doi.org/10.1016/j.cancergen.2014.02.004
Publication status	Published - 2014

Keywords

Combinations
Data mining
Neuroblastoma
SNPs

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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abstract = "Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P",

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AU - Capasso, Mario

AU - Calabrese, Francesco Maria

AU - Iolascon, Achille

AU - Mellerup, Erling

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N2 - Analysis of combinations of genetic changes that occur exclusively in patients may be a supplementary strategy to the single-locus strategy used in many genetic studies. The genotypes of 16 SNPs within susceptibility loci for neuroblastoma (NB) were analyzed in a previous study. In the present study, combinations of these genotypes have been analyzed. The theoretical number of combinations of 3 SNP genotypes taken from 16 SNPs is 15,120. Of these, 14,307 were found in 370 patients and 803 controls; 12,772 combinations were common to both patients and controls; 1,213 were found in controls only; and 322 combinations were found in patients only. Among thelatter, a cluster of 24 combinations was found to be significantly associated with NB (P

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