Object: Since psychotropic polytherapy is widely used despite limited evidence of efficacy and safety, we evaluated combinations of mood-stabilizers with antipsychotics. We also compared current findings with prior samples, to evaluate changes in psychotropic prescription practices involving antipsychotic-mood stabilizer treated inpatients. Method: Medical records of McLean Hospital inpatients treated with antipsychotics for ≥ 3 consecutive days during March-May 2002 were reviewed. In 344 inpatients prescribed an antipsychotic in 2002, we contrasted those also given a mood-stabilizer or not regarding clinical features, type and doses of all psychotropics, and clinical changes during hospitalization. Results: Mood-stabilizers were given to 63.7% (n=219) of antipsychotic-treated subjects. Usage ranked: divalproex > gabapentin > lithium > lamotrigine = topiramate > carbamazepine > oxcarbazepine > levitiracetam; 22% (n=76) of all 344 subjects received ≥ 2 mood-stabilizers. Diagnoses associated with combination-treatment ranked: major affective (54%) > primary psychotic (26%) > other (19%). Conclusions: Mood-stabilizer co-treatment remains prevalent, particularly combinations of anticonvulsants with modern antipsychotics.
|Number of pages||5|
|Publication status||Published - Oct 2006|
- Antipsychotic combination therapy
- Mood stabilizer
ASJC Scopus subject areas
- Psychiatry and Mental health