Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction

Mario Petretta, Alberto Cuocolo, Emanuele Nicolai, Wanda Acampa, Marco Salvatore, Domenico Bonaduce

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background. This study evaluated the prognostic value of combined assessment of left ventricular (LV) function and regional myocardial thallium activity in patients with nonrecent myocardial infarction and LV dysfunction. Methods and Results. Eighty-two patients with previous myocardial infarction (> 8 weeks) and echocardiographic evidence of LV dysfunction underwent thallium-201 rest-redistribution tomography and cardiac catheterization. During the follow-up period (mean 25 months) there were 18 cardiac events (14 deaths and 4 nonfatal myocardial infarctions). Multivariate Cox regression analysis on clinical, angiographic, and thallium variables showed that the number of echocardiographic dysfunctional segments with preserved thallium uptake (≤ 50% of peak activity; chi-square 11.03; p <0.005) and age (chi-square 8.12, p <0.01) were predictive of poor outcome. At incremental analysis, combined echocardiographic and thallium data provided significant additional information to clinical, thallium, and LV functional data, increasing global chi-square value from 22.4 to 31.5 (p <0.01). Similarly, combined data gave additional information after considering clinical, echocardiographic, and LV functional data, increasing global chi-square from 17.8 to 22.3 (p <0.05). Differently, the number of diseased vessels at coronary angiography did not add further prognostic information. Conclusions. In patients with previous myocardial infarction and chronic LV dysfunction, the combination of echocardiographic and thallium rest-redistribution imaging data gives prognostic information incremental to those of clinical and LV functional data and to those of each technique considered separately.

Original languageEnglish
Pages (from-to)378-386
Number of pages9
JournalJournal of Nuclear Cardiology
Volume5
Issue number4
DOIs
Publication statusPublished - Jul 1998

Fingerprint

Thallium
Left Ventricular Dysfunction
Left Ventricular Function
Coronary Artery Disease
Myocardial Infarction
Cardiac Catheterization
Coronary Angiography
Tomography
Regression Analysis

Keywords

  • Coronary artery disease
  • Echocardiography
  • Left ventricular function
  • SPECT

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{349e9fe473e14e149c9888f71b598a35,
title = "Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction",
abstract = "Background. This study evaluated the prognostic value of combined assessment of left ventricular (LV) function and regional myocardial thallium activity in patients with nonrecent myocardial infarction and LV dysfunction. Methods and Results. Eighty-two patients with previous myocardial infarction (> 8 weeks) and echocardiographic evidence of LV dysfunction underwent thallium-201 rest-redistribution tomography and cardiac catheterization. During the follow-up period (mean 25 months) there were 18 cardiac events (14 deaths and 4 nonfatal myocardial infarctions). Multivariate Cox regression analysis on clinical, angiographic, and thallium variables showed that the number of echocardiographic dysfunctional segments with preserved thallium uptake (≤ 50{\%} of peak activity; chi-square 11.03; p <0.005) and age (chi-square 8.12, p <0.01) were predictive of poor outcome. At incremental analysis, combined echocardiographic and thallium data provided significant additional information to clinical, thallium, and LV functional data, increasing global chi-square value from 22.4 to 31.5 (p <0.01). Similarly, combined data gave additional information after considering clinical, echocardiographic, and LV functional data, increasing global chi-square from 17.8 to 22.3 (p <0.05). Differently, the number of diseased vessels at coronary angiography did not add further prognostic information. Conclusions. In patients with previous myocardial infarction and chronic LV dysfunction, the combination of echocardiographic and thallium rest-redistribution imaging data gives prognostic information incremental to those of clinical and LV functional data and to those of each technique considered separately.",
keywords = "Coronary artery disease, Echocardiography, Left ventricular function, SPECT",
author = "Mario Petretta and Alberto Cuocolo and Emanuele Nicolai and Wanda Acampa and Marco Salvatore and Domenico Bonaduce",
year = "1998",
month = "7",
doi = "10.1016/S1071-3581(98)90143-X",
language = "English",
volume = "5",
pages = "378--386",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Combined assessment of left ventricular function and rest-redistribution regional myocardial thallium-201 activity for prognostic evaluation of patients with chronic coronary artery disease and left ventricular dysfunction

AU - Petretta, Mario

AU - Cuocolo, Alberto

AU - Nicolai, Emanuele

AU - Acampa, Wanda

AU - Salvatore, Marco

AU - Bonaduce, Domenico

PY - 1998/7

Y1 - 1998/7

N2 - Background. This study evaluated the prognostic value of combined assessment of left ventricular (LV) function and regional myocardial thallium activity in patients with nonrecent myocardial infarction and LV dysfunction. Methods and Results. Eighty-two patients with previous myocardial infarction (> 8 weeks) and echocardiographic evidence of LV dysfunction underwent thallium-201 rest-redistribution tomography and cardiac catheterization. During the follow-up period (mean 25 months) there were 18 cardiac events (14 deaths and 4 nonfatal myocardial infarctions). Multivariate Cox regression analysis on clinical, angiographic, and thallium variables showed that the number of echocardiographic dysfunctional segments with preserved thallium uptake (≤ 50% of peak activity; chi-square 11.03; p <0.005) and age (chi-square 8.12, p <0.01) were predictive of poor outcome. At incremental analysis, combined echocardiographic and thallium data provided significant additional information to clinical, thallium, and LV functional data, increasing global chi-square value from 22.4 to 31.5 (p <0.01). Similarly, combined data gave additional information after considering clinical, echocardiographic, and LV functional data, increasing global chi-square from 17.8 to 22.3 (p <0.05). Differently, the number of diseased vessels at coronary angiography did not add further prognostic information. Conclusions. In patients with previous myocardial infarction and chronic LV dysfunction, the combination of echocardiographic and thallium rest-redistribution imaging data gives prognostic information incremental to those of clinical and LV functional data and to those of each technique considered separately.

AB - Background. This study evaluated the prognostic value of combined assessment of left ventricular (LV) function and regional myocardial thallium activity in patients with nonrecent myocardial infarction and LV dysfunction. Methods and Results. Eighty-two patients with previous myocardial infarction (> 8 weeks) and echocardiographic evidence of LV dysfunction underwent thallium-201 rest-redistribution tomography and cardiac catheterization. During the follow-up period (mean 25 months) there were 18 cardiac events (14 deaths and 4 nonfatal myocardial infarctions). Multivariate Cox regression analysis on clinical, angiographic, and thallium variables showed that the number of echocardiographic dysfunctional segments with preserved thallium uptake (≤ 50% of peak activity; chi-square 11.03; p <0.005) and age (chi-square 8.12, p <0.01) were predictive of poor outcome. At incremental analysis, combined echocardiographic and thallium data provided significant additional information to clinical, thallium, and LV functional data, increasing global chi-square value from 22.4 to 31.5 (p <0.01). Similarly, combined data gave additional information after considering clinical, echocardiographic, and LV functional data, increasing global chi-square from 17.8 to 22.3 (p <0.05). Differently, the number of diseased vessels at coronary angiography did not add further prognostic information. Conclusions. In patients with previous myocardial infarction and chronic LV dysfunction, the combination of echocardiographic and thallium rest-redistribution imaging data gives prognostic information incremental to those of clinical and LV functional data and to those of each technique considered separately.

KW - Coronary artery disease

KW - Echocardiography

KW - Left ventricular function

KW - SPECT

UR - http://www.scopus.com/inward/record.url?scp=0031711483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031711483&partnerID=8YFLogxK

U2 - 10.1016/S1071-3581(98)90143-X

DO - 10.1016/S1071-3581(98)90143-X

M3 - Article

C2 - 9715982

AN - SCOPUS:0031711483

VL - 5

SP - 378

EP - 386

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 4

ER -