Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic Restless Legs Syndrome patients

G. Rizzo, D. Manners, R. Vetrugno, C. Tonon, E. Malucelli, G. Plazzi, S. Marconi, F. Pizza, C. Testa, F. Provini, P. Montagna, R. Lodi

Research output: Contribution to journalArticlepeer-review

Abstract

Background and purpose: The aim of this study was to evaluate the presence of abnormalities in the brain of patients with restless legs syndrome (RLS) using voxel-based morphometry and diffusion tensor imaging (DTI). Methods: Twenty patients and twenty controls were studied. Voxel-based morphometry analysis was performed using statistical parametric mapping (SPM8) and FSL-VBM software tools. For voxel-wise analysis of DTI, tract-based spatial statistics (TBSS) and SPM8 were used. Results: Applying an appropriate threshold of probability, no significant results were found either in comparison or in correlation analyses. Conclusions: Our data argue against clear structural or microstructural abnormalities in the brain of patients with idiopathic RLS, suggesting a prevalent role of functional or metabolic impairment.

Original languageEnglish
Pages (from-to)1045-1049
Number of pages5
JournalEuropean Journal of Neurology
Volume19
Issue number7
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Diffusion tensor imaging
  • Restless legs syndrome
  • Statistical parametric mapping
  • Tract-based spatial statistics
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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