Combined computational study of mechanical behaviour and drug delivery from a porous, hydroxyapatite-based bone graft

Fabio Galbusera, Laura Bertolazzi, Rossella Balossino, Gabriele Dubini

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This paper presents a numerical model of a porous, hydroxyapatite-based bone graft also suitable as a drug delivery device. The graft was positioned in different sites and with different porosities inside a human femur model. The structural analyses were carried out to verify the graft mechanical strength, using the Tsai-Wu criterion, and the maximum porosity at which static failure does not occur. A local stress shielding risk was also calculated as the ratio between the bone stress in the intact condition and the stress after implantation of the graft. Drug release kinetics was calculated by means of the finite element method. High porosity grafts were found to fail in all implantation sites. Lower porosity grafts showed to have adequate strength if implanted in some positions, while provided insufficient resistance for other implantation sites. Drug release kinetics was found to be strongly dependent both on the porosity of the graft and the bone density near the bone-graft interface.

Original languageEnglish
Pages (from-to)209-216
Number of pages8
JournalBiomechanics and Modeling in Mechanobiology
Volume8
Issue number3
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Hydroxyapatite
Drug Delivery
Durapatite
Mechanical Behavior
Porosity
Drug delivery
Bone
Grafts
Implantation
Transplants
Bone and Bones
Pharmaceutical Preparations
Drugs
Kinetics
Pharmacokinetics
Finite Element Method
Verify
Density (specific gravity)
Shielding
Bone Density

Keywords

  • Drug delivery
  • Graft mechanical strength
  • Hydroxyapatite bone graft
  • Numerical modelling

ASJC Scopus subject areas

  • Biotechnology
  • Mechanical Engineering
  • Modelling and Simulation

Cite this

Combined computational study of mechanical behaviour and drug delivery from a porous, hydroxyapatite-based bone graft. / Galbusera, Fabio; Bertolazzi, Laura; Balossino, Rossella; Dubini, Gabriele.

In: Biomechanics and Modeling in Mechanobiology, Vol. 8, No. 3, 06.2009, p. 209-216.

Research output: Contribution to journalArticle

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