Combined determination of serum CA 19–9 and tissue polypeptide antigen: Why no improvement in pancreatic cancer diagnosis?

D. Basso, C. Fabris, G. del Favero, A. Panucci, M. Plebani, C. Angonese, G. Leandro, G. Dodi, A. Burlina, Remo Naccarato

Research output: Contribution to journalArticle

Abstract

CA 19-9 and tissue polypeptide antigen (TPA) were determined in the sera of 28 control subjects. 29 patients with pancreatic cancer, 26 with chronic pancreatitis and 62 with benign and malignant extra pancreatic diseases in order to compare their usefulness in diagnosing pancreatic cancer, to verify whether the combined assessment of the two indices could improve the results given by a single parameter and to speculate on the role of liver dysfunction in increasing their serum levels. The sensitivity, specificity and accuracy of CA 19-9 and TPA in diagnosing pancreatic malignancy were: 76. 85 and 61% for CA 19-9 and 79. 52 and 32% lor TPA. The receiver-operating characteristic curves showed that CA 19-9 and TPA similarly discriminate pancreatic cancer from controls and chronic pancreatitis, while CA 19-9 is more useful than TPA in differentiat- ing pancreatic malignancy from benign and malignant extra pancreatic abdominal diseases. TPA did not seem to add further information as compared to CA 19-9 alone when both markers were combined. Liver dysfunction may contribute to increasing serum levels of both markers.

Original languageEnglish
Pages (from-to)24-29
Number of pages6
JournalOncology
Volume45
Issue number1
DOIs
Publication statusPublished - 1988

Keywords

  • CA 19-9
  • Pancreatic cancer
  • Tissue polypeptide antigen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Basso, D., Fabris, C., del Favero, G., Panucci, A., Plebani, M., Angonese, C., Leandro, G., Dodi, G., Burlina, A., & Naccarato, R. (1988). Combined determination of serum CA 19–9 and tissue polypeptide antigen: Why no improvement in pancreatic cancer diagnosis? Oncology, 45(1), 24-29. https://doi.org/10.1159/000226525