Combined DTI–fMRI Analysis for a Quantitative Assessment of Connections Between WM Bundles and Their Peripheral Cortical Fields in Verbal Fluency

Elisa Scaccianoce, Maria Marcella Laganà, Francesca Baglio, Maria Giulia Preti, Niels Bergsland, Pietro Cecconi, Mario Clerici, Giuseppe Baselli, George Papadimitriou, Nikos Makris

Research output: Contribution to journalArticle

Abstract

Diffusion tensor imaging (DTI) tractography and functional magnetic resonance imaging (fMRI) are powerful techniques to elucidate the anatomical and functional aspects of brain connectivity. However, integrating these approaches to describe the precise link between structure and function within specific brain circuits remains challenging. In this study, a novel DTI–fMRI integration method is proposed, to provide the topographical characterization and the volumetric assessment of the functional and anatomical connections within the language circuit. In a group of 21 healthy elderly subjects (mean age 68.5 ± 5.8 years), the volume of connection between the cortical activity elicited by a verbal fluency task and the cortico-cortical fiber tracts associated with this function are mapped and quantified. An application of the method to a case study in neuro-rehabilitation context is also presented. Integrating structural and functional data within the same framework, this approach provides an overall view of white and gray matter when studying specific brain circuits.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalBrain Topography
DOIs
Publication statusAccepted/In press - Aug 10 2016

Fingerprint

Brain
Diffusion Tensor Imaging
Healthy Volunteers
Language
Rehabilitation
Magnetic Resonance Imaging
White Matter
Gray Matter

Keywords

  • Diffusion tensor imaging (DTI)
  • Functional magnetic resonance imaging (fMRI)
  • Language
  • Mapping brain connectivity
  • Multimodal imaging

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Combined DTI–fMRI Analysis for a Quantitative Assessment of Connections Between WM Bundles and Their Peripheral Cortical Fields in Verbal Fluency. / Scaccianoce, Elisa; Laganà, Maria Marcella; Baglio, Francesca; Preti, Maria Giulia; Bergsland, Niels; Cecconi, Pietro; Clerici, Mario; Baselli, Giuseppe; Papadimitriou, George; Makris, Nikos.

In: Brain Topography, 10.08.2016, p. 1-10.

Research output: Contribution to journalArticle

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