Combined effect of obesity and diabetes on early breast cancer outcome: A prospective observational study

Giuseppe Buono, Anna Crispo, Mario Giuliano, Carmine de Angelis, Francesco Schettini, Valeria Forestieri, Rossella Lauria, Matilde Pensabene, Michelino de Laurentiis, Livia Silvia Adriana Augustin, Alfonso Amore, Massimiliano D'Aiuto, Raffaele Tortoriello, Antonello Accurso, Ernesta Cavalcanti, Gerardo Botti, Maurizio Montella, Sabino de Placido, Grazia Arpino

Research output: Contribution to journalArticlepeer-review


Background: Previous studies suggested that obesity and diabetes were correlated with breast cancer outcome. The aim of the present study was to investigate the prognostic effect of obesity and diabetes on the outcome of early breast cancer patients. Materials and Methods: Overall, 841 early breast cancer patients were prospectively enrolled between January 2009 and December 2013. Study population was divided into four groups: (1) patients without obesity or diabetes; (2) patients with only diabetes; (3) patients with only obesity; and (4) patients with both diabetes and obesity. Categorical variables were analyzed by the chi-square test and survival data by the log-rank test. Results: At diagnosis, obese and diabetic patients were more likely to be older (p < 0.0001) and post-menopausal (p < 0.0001) and to have a tumor larger than 2 cm (p < 0.0001) than patients in groups 1-3. At univariate analyses, obese and diabetic patients had a worse disease-free survival (p = 0.01) and overall survival (p = 0.001) than did patients without obesity and diabetes. At multivariate analyses, the co-presence of obesity and diabetes was an independent prognostic factor for diseasefree survival (hazard ratio=2.62, 95% CI 1.23-5.60) but not for overall survival. Conclusions: At diagnosis, patients with obesity and diabetes were older, had larger tumors and a worse outcome compared to patients without obesity or diabetes. These data suggest that metabolic health influences the prognosis of patients affected by early breast cancer.

Original languageEnglish
Pages (from-to)115709-115717
Number of pages9
Issue number70
Publication statusPublished - Jan 1 2017


  • Breast cancer
  • Combined variables
  • Diabetes
  • Obesity
  • Outcome

ASJC Scopus subject areas

  • Oncology


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