Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy

Mario Petretta; Maria L E Vicario; Letizia Spinelli; Adele Ferro; Alberto Cuocolo; Mario Condorelli; Domenico Bonaduce

doi:10.1016/S1388-9842(02)00164-2

Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy

Mario Petretta, Maria L E Vicario, Letizia Spinelli, Adele Ferro, Alberto Cuocolo, Mario Condorelli, Domenico Bonaduce

IRCCS SDN

Research output: Contribution to journal › Article › peer-review

Abstract

The myocardial length-tension and the force-frequency relations are important mechanisms that regulate the contractile strength of the heart. Aims: To evaluate in humans the effect on left ventricular function of the interaction between the myocardial length-tension and force-frequency relations. Methods and results: Eight patients with dilated cardiomyopathy (DCM) and 6 control subjects underwent radionuclide monitoring of left ventricular function during atrial pacing, saline loading and atrial pacing at the end of saline loading. In controls, atrial pacing reduced left ventricular end-diastolic (P

Original language	English
Pages (from-to)	727-735
Number of pages	9
Journal	European Journal of Heart Failure
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/S1388-9842(02)00164-2
Publication status	Published - Dec 2002

Keywords

Contractility spectrum
Heart failure
Heart rate
Myocardial infarction
Pacing
Ventricular function

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S1388-9842(02)00164-2

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Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy. / Petretta, Mario; Vicario, Maria L E; Spinelli, Letizia; Ferro, Adele; Cuocolo, Alberto; Condorelli, Mario; Bonaduce, Domenico.

In: European Journal of Heart Failure, Vol. 4, No. 6, 12.2002, p. 727-735.

Research output: Contribution to journal › Article › peer-review

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AU - Condorelli, Mario

AU - Bonaduce, Domenico

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