Combined effect of the force-frequency and length-tension mechanisms on left ventricular function in patients with dilated cardiomyopathy

Mario Petretta, Maria L E Vicario, Letizia Spinelli, Adele Ferro, Alberto Cuocolo, Mario Condorelli, Domenico Bonaduce

Research output: Contribution to journalArticlepeer-review

Abstract

The myocardial length-tension and the force-frequency relations are important mechanisms that regulate the contractile strength of the heart. Aims: To evaluate in humans the effect on left ventricular function of the interaction between the myocardial length-tension and force-frequency relations. Methods and results: Eight patients with dilated cardiomyopathy (DCM) and 6 control subjects underwent radionuclide monitoring of left ventricular function during atrial pacing, saline loading and atrial pacing at the end of saline loading. In controls, atrial pacing reduced left ventricular end-diastolic (P

Original languageEnglish
Pages (from-to)727-735
Number of pages9
JournalEuropean Journal of Heart Failure
Volume4
Issue number6
DOIs
Publication statusPublished - Dec 2002

Keywords

  • Contractility spectrum
  • Heart failure
  • Heart rate
  • Myocardial infarction
  • Pacing
  • Ventricular function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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