Moloney-virus-induced lymphoma LSTRA of BALB c origin was inoculated i.p. into histocompatible CD2F1 mice or into allogenic BD2F1 hosts incompatible for multiple minor histocompatibility loci (MMHL). All untreated mice died with comparable median survival times (MST). However, when recipients were subjected to i.p. treatment with BCG or inactivated Candida albicans (CA), significant antitumor effects were detected if the non-specific immunoadjuvants (IA) were given before (on day - 14) and after (on day + 1) tumor challenge. The efficiency of IA was found to be higher in MMHL incompatible mice than in CD2F1 hosts. Chemotherapy experiments were conducted in histocompatible mice using IA given according to various treatment schedules, in combinations with 3 nitrosoureas of clinical interest (i.e. BCNU, CCNU and Me-CCNU). Synergistic antitumor effects were evidenced when the antineoplastic agents were associated with IA administered on the "- 14 + 1" regimen. These results pointed out that the antilymphoma effects of chemotherapy could be amplified by IA only when the treatment schedule included adjuvants administration prior to tumor challenge.
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