Combined epirubicin and interleukin-2 regimen in the treatment of malignant mesothelioma: A multicenter phase II study of the Italian group on rare tumors

Sergio Bretti, Alfredo Berruti, Luigi Dogliotti, Bruno Castagneto, Rossella Bertulli, Pietro Spadaro, Giuseppe Toscano, Paolo Astorre, Claudio Verusio, Rita Lionetto, Paolo Bruzzi, Armando Santoro

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Abstract

The Italian Group on Rare Tumors undertook a phase II study of a combination of epirubicin and interleukin-2 in 21 chemotherapy-naive patients with malignant mesothelioma. All patients had bidimensionally measurable disease at CT scan. Treatment included intravenous administration of epirubicin at a dose of 110 mg/m2 i.v. on day 1, and interleukin-2 at a dose of 9 MU subcutaneously from day 8 to day 12 and from day 15 to day 19. Cycles were repeated every three weeks, up to six times in the absence of progressive disease. Treatment response was evaluated after two cycles of therapy. Only one patient achieved a partial response, resulting in an overall response rate of 5% (1/21) with a median progression-free and overall survival of 5 and 10 months, respectively. Toxicity was relevant and caused treatment discontinuation in many patients. These results do not support the use of such a combination in the management of malignant mesothelioma.

Original languageEnglish
Pages (from-to)558-561
Number of pages4
JournalTumori
Volume84
Issue number5
Publication statusPublished - Sep 1998

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Keywords

  • Epirubicin
  • Interleukin-2
  • Mesothelioma

ASJC Scopus subject areas

  • Cancer Research

Cite this

Bretti, S., Berruti, A., Dogliotti, L., Castagneto, B., Bertulli, R., Spadaro, P., Toscano, G., Astorre, P., Verusio, C., Lionetto, R., Bruzzi, P., & Santoro, A. (1998). Combined epirubicin and interleukin-2 regimen in the treatment of malignant mesothelioma: A multicenter phase II study of the Italian group on rare tumors. Tumori, 84(5), 558-561.