Combined evaluation of resting IGF1, N-terminal propeptide of type III procollagen and C-terminal cross-linked telopeptide of type I collagen levels might be useful for detecting inappropriate GH administration in female athletes

Luigi di Luigi, Antonello E. Rigamonti, Fiorenza Agosti, Monica Mencarelli, Paolo Sgró, Nicoletta Marazzi, Silvano G. Cella, Eugenio E. Müller, Alessandro Sartorio

Research output: Contribution to journalArticle

Abstract

Objective: To detect exogenous recombinant human GH (rhGH) abuse in female athletes. Design: GH-dependent markers were assayed in serum of 100 female athletes (control group) and in a subgroup of nine female subjects treated with rhGH (0.09 IU/kg body weight, 6 days/week for 3 weeks). Methods: Cut-off values (mean + 2 S.D.) for IGF1, N-terminal propeptide of type III procollagen (PIIINP) and C-terminal telopeptide of type I collagen (ICTP) were calculated and arbitrary scores (1.5 or 2.0) were assigned to abnormal markers. By using the sum of individual marker scores, positive (≥3) or negative (

Original languageEnglish
Pages (from-to)753-758
Number of pages6
JournalEuropean Journal of Endocrinology
Volume160
Issue number5
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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