Combined HLA matched limbal stem cells allograft with amniotic membrane transplantation as a prophylactic surgical procedure to prevent corneal graft rejection after penetrating keratoplasty: Case report

Research output: Contribution to journalArticle

Abstract

Purpose. To determine if the use of combined HLA matched limbal stem cells allograft with amniotic membrane transplantation (AMT) is a safe and effective prophylactic surgical procedure to prevent corneal graft after penetrating keratoplasty (PK).

Methods. We report the case of a 17 years old patient with a history of congenital glaucoma, trabeculectomy and multiple corneal graft rejections, presenting total limbal cell deficiency. To reduce the possibility of graft rejection in the left eye after a new PK, a two step procedure was performed. At first the patient underwent a combined HLA matched limbal stem cells allograft (LAT) and AMT and then, 10 months later, a new PK.

Results. During 12 months of follow-up, the corneal graft remained stable and smooth, with no sign of graft rejection.

Conclusions. In our patient, the prophylactic use of LAT from HLA-matched donors and AMT before PK, may result in a better prognosis of corneal graft survival.

Original languageEnglish
Pages (from-to)298-300
Number of pages3
JournalAnnali dell'Istituto Superiore di Sanita
Volume50
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Amniotic membrane transplantation
  • Corneal transplantation
  • HLA matched allograft
  • Limbal stem cells

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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