Combined kidney and liver transplantation for familial haemolytic uraemic syndrome

Giuseppe Remuzzi, Piero Ruggenenti, Daniela Codazzi, Marina Noris, Jessica Caprioli, Giuseppe Locatelli, Bruno Gridelli

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Recurrent haemolytic uraemic syndrome (HUS) is a genetic form of thrombotic microangiopathy that is mostly associated with low activity of complement factor H. The disorder usually develops in families, leads to end stage renal disease, and invariably recurs after kidney transplantation. We did a simultaneous kidney and liver transplantation in a 2-year-old child with HUS and a mutation in complement factor H to restore the defective factor H, with no recurrence of the disease. The operation was successful, and at discharge, the child had healthy kidney and liver function, with no sign of haemolysis.

Original languageEnglish
Pages (from-to)1671-1672
Number of pages2
JournalLancet
Volume359
Issue number9318
DOIs
Publication statusPublished - May 11 2002

Fingerprint

Complement Factor H
Hemolytic-Uremic Syndrome
Liver Transplantation
Kidney Transplantation
Thrombotic Microangiopathies
Hemolysis
Chronic Kidney Failure
Kidney
Recurrence
Mutation
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Remuzzi, G., Ruggenenti, P., Codazzi, D., Noris, M., Caprioli, J., Locatelli, G., & Gridelli, B. (2002). Combined kidney and liver transplantation for familial haemolytic uraemic syndrome. Lancet, 359(9318), 1671-1672. https://doi.org/10.1016/S0140-6736(02)08560-4

Combined kidney and liver transplantation for familial haemolytic uraemic syndrome. / Remuzzi, Giuseppe; Ruggenenti, Piero; Codazzi, Daniela; Noris, Marina; Caprioli, Jessica; Locatelli, Giuseppe; Gridelli, Bruno.

In: Lancet, Vol. 359, No. 9318, 11.05.2002, p. 1671-1672.

Research output: Contribution to journalArticle

Remuzzi, G, Ruggenenti, P, Codazzi, D, Noris, M, Caprioli, J, Locatelli, G & Gridelli, B 2002, 'Combined kidney and liver transplantation for familial haemolytic uraemic syndrome', Lancet, vol. 359, no. 9318, pp. 1671-1672. https://doi.org/10.1016/S0140-6736(02)08560-4
Remuzzi, Giuseppe ; Ruggenenti, Piero ; Codazzi, Daniela ; Noris, Marina ; Caprioli, Jessica ; Locatelli, Giuseppe ; Gridelli, Bruno. / Combined kidney and liver transplantation for familial haemolytic uraemic syndrome. In: Lancet. 2002 ; Vol. 359, No. 9318. pp. 1671-1672.
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