Combined Liver-Kidney Transplantation-S. Orsola Experience

Nephrological Aspects

G. Mosconi, M. P. Scolari, G. Feliciangeli, G. Liviano D'Arcangelo, A. Buscaroli, F. D'Addio, D. Conte, A. Faenza, A. D. Pinna, S. Stefoni

Research output: Contribution to journalArticle

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Abstract

Combined liver kidney transplantation (LKT) has the potential to provide a complete recovery of liver and kidney failure; the literature reports an increase in LKT in the last few years and an improvement in patient and graft survival. In our experience 15 patients underwent LKT from 1997 to 2005. The mean age was 50 ± 9 years (range 34 to 63). The patients were affected by viral (n = 9), alcoholic (n = 1), polycystic (n = 2), cholangitis (n = 1), cholestatic (n = 1), or amyloidotic (n = 1) chronic hepatopathy. Chronic renal failure (CRF) was due to polycystic kidney disease (n = 4), IgA (n = 2), interstitial nephropathy (n = 2), glomerulonephritis (n = 4), amyloidosis (n = 1), vascular nephropathy (n = 1), of unknown end-stage renal disease (n = 1). Twelve of 15 patients were on renal dialysis treatment, three patients had moderate/severe CRF. Two patients had previously been transplanted (kidney). All patients were selected based upon blood group identity and negative cross-match before kidney transplant. Histocompatibility matching (HLA) was not included in the selection criteria. We did not observe delayed graft function. After a mean follow-up was 23 ± 32 months (range 5 to 99), 12 subjects show, normal hepatic and renal function. At the beginning of our experience two patients in bad clinical condition died within 3 months because of sepsis, and one died because of a malignancy after 7 years. Both organs were functioning well in the deceased patients. Survival analysis confirms LKT efficacy: at 5 years follow-up patient survival is 86%, graft survival censored for death 100%. Only two subjects had an acute rejection episode in the first year; the kidney rejection incidence was lower than that reported for an isolated kidney transplant (13% vs 21%).

Original languageEnglish
Pages (from-to)1122-1124
Number of pages3
JournalTransplantation Proceedings
Volume38
Issue number4
DOIs
Publication statusPublished - May 2006

Fingerprint

Liver Transplantation
Kidney Transplantation
Kidney
Chronic Kidney Failure
Graft Survival
Delayed Graft Function
Transplants
Polycystic Kidney Diseases
Histocompatibility
Cholangitis
Liver Failure
Amyloidosis
Survival Analysis
Blood Group Antigens
Glomerulonephritis
Immunoglobulin A
Patient Selection
Renal Insufficiency
Blood Vessels
Renal Dialysis

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Mosconi, G., Scolari, M. P., Feliciangeli, G., D'Arcangelo, G. L., Buscaroli, A., D'Addio, F., ... Stefoni, S. (2006). Combined Liver-Kidney Transplantation-S. Orsola Experience: Nephrological Aspects. Transplantation Proceedings, 38(4), 1122-1124. https://doi.org/10.1016/j.transproceed.2006.03.063

Combined Liver-Kidney Transplantation-S. Orsola Experience : Nephrological Aspects. / Mosconi, G.; Scolari, M. P.; Feliciangeli, G.; D'Arcangelo, G. Liviano; Buscaroli, A.; D'Addio, F.; Conte, D.; Faenza, A.; Pinna, A. D.; Stefoni, S.

In: Transplantation Proceedings, Vol. 38, No. 4, 05.2006, p. 1122-1124.

Research output: Contribution to journalArticle

Mosconi, G, Scolari, MP, Feliciangeli, G, D'Arcangelo, GL, Buscaroli, A, D'Addio, F, Conte, D, Faenza, A, Pinna, AD & Stefoni, S 2006, 'Combined Liver-Kidney Transplantation-S. Orsola Experience: Nephrological Aspects', Transplantation Proceedings, vol. 38, no. 4, pp. 1122-1124. https://doi.org/10.1016/j.transproceed.2006.03.063
Mosconi, G. ; Scolari, M. P. ; Feliciangeli, G. ; D'Arcangelo, G. Liviano ; Buscaroli, A. ; D'Addio, F. ; Conte, D. ; Faenza, A. ; Pinna, A. D. ; Stefoni, S. / Combined Liver-Kidney Transplantation-S. Orsola Experience : Nephrological Aspects. In: Transplantation Proceedings. 2006 ; Vol. 38, No. 4. pp. 1122-1124.
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