Combined modality treatment of locally advanced lung cancer

Mauro G. Trovò, Marco Gigante, Emilio Minatel, Carlo Gobitti, Giovanni Franchin

Research output: Contribution to journalArticle


This paper describes the mechanisms of action of ionizing radiations combined with antineoplastic drugs. Some relevant drugs for the combined modality treatments of locally advanced lung cancer are reported. The meta- analyses including randomized trials comparing single agent (radiotherapy or chemotherapy) versus combined chemotherapy and radiotherapy in patients with unresectable non small cell lung cancer and limited small cell lung cancer are then reviewed. The clinical outcome in relation to different schedules of chemoradiotherapy (sequential, alternating and concurrent) is also focussed.

Original languageEnglish
Pages (from-to)259-269
Number of pages11
Issue number2
Publication statusPublished - Mar 1998


  • Chemotherapy
  • Combined modality
  • Lung cancer
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research

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  • Cite this

    Trovò, M. G., Gigante, M., Minatel, E., Gobitti, C., & Franchin, G. (1998). Combined modality treatment of locally advanced lung cancer. Tumori, 84(2), 259-269.