Komibinierte neuronale und endokrine tumoren der sellaregion

Translated title of the contribution: Combined neuronal and endocrine tumors of the sellar region

W. Saeger, D. K. Lüdecke, M. Losa

Research output: Contribution to journalArticle

Abstract

Gangliocytomas or gangliogliomas of the sellar region are very rare tumors. In a great proportion of those cases an adenoma of the anterior pituitary develops from the cell type that is hyperstimulated by the releasing hormone produced from the gangliocytoma. Five GHRH secreting gangliocytomas are re ported four of these were localized adjacent to a GH secreting adenoma. In one case, no adenoma tissue was found beside the ganglicytoma. As only the adenomas can secrete GH, the adenomas and not the gangliocytomas are directly responsible for acromegaly so that such an adenoma has to be present in cases of acromegaly. A CRH secreting gangliocytoma was combined with an ACTH cell adenoma that had induced Cushing's disease. A ganglioglioma of the posterior pituitary had led to an inappropriate secretion of Vasopressin. The morphology of the different tumors is presented.

Translated title of the contributionCombined neuronal and endocrine tumors of the sellar region
Original languageGerman
Pages (from-to)419-424
Number of pages6
JournalPathologe
Volume18
Issue number6
DOIs
Publication statusPublished - Nov 1997

Keywords

  • Electron microscopy
  • Gangliocytoma
  • Ganglioglioma
  • Immunohistochemistry
  • Pituitary adenoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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