Abstract
Fine-needle cytology (FNC) is frequently used to diagnose thyroid nodules discovered by palpation or imaging studies. Molecular tests on FNC material may increase its diagnostic accuracy. We report a case of a classic papillary thyroid carcinoma combined with a mucoepidermoid carcinoma correctly identified on FNC. The papillary component had a classic immunophenotype (CK19+, TTF1+), while the mucoepidermoid one was only focally CK19+. Point mutations (BRAF and RAS) and rearrangements (RET/PTC) of the papillary component have been also investigated on FNC samples, with resulting concurrent rearrangements of RET/PTC1 and RET/PTC3, but no point mutations. The histogenesis of combined papillary and mucoepidermoid carcinoma of the thyroid still remains partly unsettled, and further genomic studies are needed to shed some more light on this peculiar neoplasm.
| Original language | English |
|---|---|
| Article number | 7 |
| Pages (from-to) | 140-144 |
| Number of pages | 5 |
| Journal | Endocrine Pathology |
| Volume | 26 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 14 2015 |
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Keywords
- BRAF and RAS point mutations
- Fine-needle cytology
- Papillary thyroid carcinoma
- RET/PTC rearrangement
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Combined Papillary and Mucoepidermoid Carcinoma of the Thyroid Gland : a Possible Collision Tumor Diagnosed on Fine-Needle Cytology. Report of a Case with Immunocytochemical and Molecular Correlations. / Fulciniti, Franco; Vuttariello, Emilia; Calise, Celeste; Monaco, Mario; Pezzullo, Luciano; Chiofalo, Maria Grazia; Di Gennaro, Francesca; Malzone, Maria Gabriella; Campanile, Anna Cipolletta; Losito, Nunzia Simona; Botti, Gerardo; Chiappetta, Gennaro.
In: Endocrine Pathology, Vol. 26, No. 2, 7, 14.03.2015, p. 140-144.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combined Papillary and Mucoepidermoid Carcinoma of the Thyroid Gland
T2 - a Possible Collision Tumor Diagnosed on Fine-Needle Cytology. Report of a Case with Immunocytochemical and Molecular Correlations
AU - Fulciniti, Franco
AU - Vuttariello, Emilia
AU - Calise, Celeste
AU - Monaco, Mario
AU - Pezzullo, Luciano
AU - Chiofalo, Maria Grazia
AU - Di Gennaro, Francesca
AU - Malzone, Maria Gabriella
AU - Campanile, Anna Cipolletta
AU - Losito, Nunzia Simona
AU - Botti, Gerardo
AU - Chiappetta, Gennaro
PY - 2015/3/14
Y1 - 2015/3/14
N2 - Fine-needle cytology (FNC) is frequently used to diagnose thyroid nodules discovered by palpation or imaging studies. Molecular tests on FNC material may increase its diagnostic accuracy. We report a case of a classic papillary thyroid carcinoma combined with a mucoepidermoid carcinoma correctly identified on FNC. The papillary component had a classic immunophenotype (CK19+, TTF1+), while the mucoepidermoid one was only focally CK19+. Point mutations (BRAF and RAS) and rearrangements (RET/PTC) of the papillary component have been also investigated on FNC samples, with resulting concurrent rearrangements of RET/PTC1 and RET/PTC3, but no point mutations. The histogenesis of combined papillary and mucoepidermoid carcinoma of the thyroid still remains partly unsettled, and further genomic studies are needed to shed some more light on this peculiar neoplasm.
AB - Fine-needle cytology (FNC) is frequently used to diagnose thyroid nodules discovered by palpation or imaging studies. Molecular tests on FNC material may increase its diagnostic accuracy. We report a case of a classic papillary thyroid carcinoma combined with a mucoepidermoid carcinoma correctly identified on FNC. The papillary component had a classic immunophenotype (CK19+, TTF1+), while the mucoepidermoid one was only focally CK19+. Point mutations (BRAF and RAS) and rearrangements (RET/PTC) of the papillary component have been also investigated on FNC samples, with resulting concurrent rearrangements of RET/PTC1 and RET/PTC3, but no point mutations. The histogenesis of combined papillary and mucoepidermoid carcinoma of the thyroid still remains partly unsettled, and further genomic studies are needed to shed some more light on this peculiar neoplasm.
KW - BRAF and RAS point mutations
KW - Fine-needle cytology
KW - Papillary thyroid carcinoma
KW - RET/PTC rearrangement
UR - http://www.scopus.com/inward/record.url?scp=84939998998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939998998&partnerID=8YFLogxK
U2 - 10.1007/s12022-015-9364-9
DO - 10.1007/s12022-015-9364-9
M3 - Article
C2 - 25771987
AN - SCOPUS:84939998998
VL - 26
SP - 140
EP - 144
JO - Endocrine Pathology
JF - Endocrine Pathology
SN - 1046-3976
IS - 2
M1 - 7
ER -