Abstract
Between August 1979 and August 1984, 46 untreated, inoperable patients with advanced squamous cell carcinoma of the head and neck were submitted to a combined modality of treatment based on four courses of polychemotherapy (vincristine, bleomycin, and methotrexate), rotated with three courses of radiotherapy, 20 Gy each. Forty‐six patients entered the study: 45 were evaluable for their response to the treatment and 46 for toxicity effects. We observed 26 complete responses (57.7%) and 14 partial responses (31.1%); overall actuarial survival was 28% at 55 months. Mucositis occurred in 11 patients, 3 patients suffered from nausea and vomiting, 2 patients developed fever, and 1 had a platelet count of 50,000/mm3. One toxic death occurred: one patient developed an acute renal failure related to Methotrexate.
| Original language | English |
|---|---|
| Pages (from-to) | 74-77 |
| Number of pages | 4 |
| Journal | Head & Neck Surgery |
| Volume | 8 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 1985 |
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ASJC Scopus subject areas
- Otorhinolaryngology
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Combined polychemotherapy and radiotherapy in advanced inoperable squamous cell carcinoma of the head and neck. / Rosso, Riccardo; Merlano, Marco; Scarpati, Daniele; Grimaldi, Andrea; Bonelli, Luigina; Barbieri, Angelo.
In: Head & Neck Surgery, Vol. 8, No. 2, 01.01.1985, p. 74-77.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combined polychemotherapy and radiotherapy in advanced inoperable squamous cell carcinoma of the head and neck
AU - Rosso, Riccardo
AU - Merlano, Marco
AU - Scarpati, Daniele
AU - Grimaldi, Andrea
AU - Bonelli, Luigina
AU - Barbieri, Angelo
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Between August 1979 and August 1984, 46 untreated, inoperable patients with advanced squamous cell carcinoma of the head and neck were submitted to a combined modality of treatment based on four courses of polychemotherapy (vincristine, bleomycin, and methotrexate), rotated with three courses of radiotherapy, 20 Gy each. Forty‐six patients entered the study: 45 were evaluable for their response to the treatment and 46 for toxicity effects. We observed 26 complete responses (57.7%) and 14 partial responses (31.1%); overall actuarial survival was 28% at 55 months. Mucositis occurred in 11 patients, 3 patients suffered from nausea and vomiting, 2 patients developed fever, and 1 had a platelet count of 50,000/mm3. One toxic death occurred: one patient developed an acute renal failure related to Methotrexate.
AB - Between August 1979 and August 1984, 46 untreated, inoperable patients with advanced squamous cell carcinoma of the head and neck were submitted to a combined modality of treatment based on four courses of polychemotherapy (vincristine, bleomycin, and methotrexate), rotated with three courses of radiotherapy, 20 Gy each. Forty‐six patients entered the study: 45 were evaluable for their response to the treatment and 46 for toxicity effects. We observed 26 complete responses (57.7%) and 14 partial responses (31.1%); overall actuarial survival was 28% at 55 months. Mucositis occurred in 11 patients, 3 patients suffered from nausea and vomiting, 2 patients developed fever, and 1 had a platelet count of 50,000/mm3. One toxic death occurred: one patient developed an acute renal failure related to Methotrexate.
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U2 - 10.1002/hed.2890080203
DO - 10.1002/hed.2890080203
M3 - Article
VL - 8
SP - 74
EP - 77
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 2
ER -