Combined polychemotherapy and radiotherapy in advanced inoperable squamous cell carcinoma of the head and neck

Riccardo Rosso, Marco Merlano, Daniele Scarpati, Andrea Grimaldi, Luigina Bonelli, Angelo Barbieri

Research output: Contribution to journalArticlepeer-review

Abstract

Between August 1979 and August 1984, 46 untreated, inoperable patients with advanced squamous cell carcinoma of the head and neck were submitted to a combined modality of treatment based on four courses of polychemotherapy (vincristine, bleomycin, and methotrexate), rotated with three courses of radiotherapy, 20 Gy each. Forty‐six patients entered the study: 45 were evaluable for their response to the treatment and 46 for toxicity effects. We observed 26 complete responses (57.7%) and 14 partial responses (31.1%); overall actuarial survival was 28% at 55 months. Mucositis occurred in 11 patients, 3 patients suffered from nausea and vomiting, 2 patients developed fever, and 1 had a platelet count of 50,000/mm3. One toxic death occurred: one patient developed an acute renal failure related to Methotrexate.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalHead & Neck Surgery
Volume8
Issue number2
DOIs
Publication statusPublished - Jan 1 1985

ASJC Scopus subject areas

  • Otorhinolaryngology

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