TY - JOUR
T1 - Combined polychemotherapy and radiotherapy in advanced inoperable squamous cell carcinoma of the head and neck
AU - Rosso, Riccardo
AU - Merlano, Marco
AU - Scarpati, Daniele
AU - Grimaldi, Andrea
AU - Bonelli, Luigina
AU - Barbieri, Angelo
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Between August 1979 and August 1984, 46 untreated, inoperable patients with advanced squamous cell carcinoma of the head and neck were submitted to a combined modality of treatment based on four courses of polychemotherapy (vincristine, bleomycin, and methotrexate), rotated with three courses of radiotherapy, 20 Gy each. Forty‐six patients entered the study: 45 were evaluable for their response to the treatment and 46 for toxicity effects. We observed 26 complete responses (57.7%) and 14 partial responses (31.1%); overall actuarial survival was 28% at 55 months. Mucositis occurred in 11 patients, 3 patients suffered from nausea and vomiting, 2 patients developed fever, and 1 had a platelet count of 50,000/mm3. One toxic death occurred: one patient developed an acute renal failure related to Methotrexate.
AB - Between August 1979 and August 1984, 46 untreated, inoperable patients with advanced squamous cell carcinoma of the head and neck were submitted to a combined modality of treatment based on four courses of polychemotherapy (vincristine, bleomycin, and methotrexate), rotated with three courses of radiotherapy, 20 Gy each. Forty‐six patients entered the study: 45 were evaluable for their response to the treatment and 46 for toxicity effects. We observed 26 complete responses (57.7%) and 14 partial responses (31.1%); overall actuarial survival was 28% at 55 months. Mucositis occurred in 11 patients, 3 patients suffered from nausea and vomiting, 2 patients developed fever, and 1 had a platelet count of 50,000/mm3. One toxic death occurred: one patient developed an acute renal failure related to Methotrexate.
UR - http://www.scopus.com/inward/record.url?scp=0022155706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022155706&partnerID=8YFLogxK
U2 - 10.1002/hed.2890080203
DO - 10.1002/hed.2890080203
M3 - Article
C2 - 2416710
AN - SCOPUS:0022155706
VL - 8
SP - 74
EP - 77
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 2
ER -