Combined Prophylactic and Therapeutic Use Maximizes Hydroxychloroquine Anti-SARS-CoV-2 Effects in vitro

Nicola Clementi, Elena Criscuolo, Roberta Antonia Diotti, Roberto Ferrarese, Matteo Castelli, Lorenzo Dagna, Roberto Burioni, Massimo Clementi, Nicasio Mancini

Research output: Contribution to journalArticlepeer-review

Abstract

While the SARS-CoV-2 pandemic is heavily hitting the world, it is of extreme importance that significant in vitro observations guide the quick set up of clinical trials. In this study, we evidence that the anti-SARS-CoV2 activity of a clinically achievable hydroxychloroquine concentration is maximized only when administered before and after the infection of Vero E6 and Caco-2 cells. This suggests that only a combined prophylactic and therapeutic use of hydroxychloroquine may be effective in limiting viral replication in patients.

Original languageEnglish
Article number1704
JournalFrontiers in Microbiology
Volume11
DOIs
Publication statusPublished - Jul 10 2020

Keywords

  • COVID-19
  • hydroxychloroquine
  • prophylaxis
  • SARS-CoV-2
  • therapy

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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