TY - JOUR
T1 - Combined risk factors for melanoma in a Mediterranean population
AU - Landi, M. T.
AU - Baccarelli, A.
AU - Calista, D.
AU - Pesatori, A.
AU - Fears, T.
AU - Tucker, M. A.
AU - Landi, G.
PY - 2001/11/2
Y1 - 2001/11/2
N2 - A case - control study of non-familial melanoma including 183 incident cases and 179 controls was conducted in North-Eastern Italy to identify important risk factors and determine how combination of these affects risk in a Mediterranean population. Presence of dysplastic nevi (OR = 4.2, 95% Cl = 2.4-7.4), low propensity to tan (OR = 2.4, 95% Cl = 1.1-5.0), light eye (OR = 2.4, 95% Cl = 1.1-5.2), and light skin colour (OR = 4.1, 95% Cl = 1.4-12.1) were significantly associated with melanoma risk after adjustment for age, gender and pigmentation characteristics. A chart which identifies melanoma risk associated with combinations of these factors is presented; it can be used to identify subjects who would most benefit from preventive measures in Mediterranean populations. According to the combination of these factors, a relative risk range from 1 to 98.5 was found. Light skin colour, high number of sunburns with blistering, and low propensity to tan were significantly associated with melanoma thickness, possibly indicating that individuals with these characteristics underestimate their risk and seek attention when their lesion is already advanced.
AB - A case - control study of non-familial melanoma including 183 incident cases and 179 controls was conducted in North-Eastern Italy to identify important risk factors and determine how combination of these affects risk in a Mediterranean population. Presence of dysplastic nevi (OR = 4.2, 95% Cl = 2.4-7.4), low propensity to tan (OR = 2.4, 95% Cl = 1.1-5.0), light eye (OR = 2.4, 95% Cl = 1.1-5.2), and light skin colour (OR = 4.1, 95% Cl = 1.4-12.1) were significantly associated with melanoma risk after adjustment for age, gender and pigmentation characteristics. A chart which identifies melanoma risk associated with combinations of these factors is presented; it can be used to identify subjects who would most benefit from preventive measures in Mediterranean populations. According to the combination of these factors, a relative risk range from 1 to 98.5 was found. Light skin colour, high number of sunburns with blistering, and low propensity to tan were significantly associated with melanoma thickness, possibly indicating that individuals with these characteristics underestimate their risk and seek attention when their lesion is already advanced.
KW - Dysplastic nevi
KW - Mediterranean populations
KW - Melanoma
KW - Melanoma thickness
KW - Pigmentation
KW - Risk factors
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U2 - 10.1054/bjoc.2001.2029
DO - 10.1054/bjoc.2001.2029
M3 - Article
C2 - 11720465
AN - SCOPUS:0035798475
VL - 85
SP - 1304
EP - 1310
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 9
ER -