Combined therapy for primary central nervous system lymphoma in immunocompetent patients

A. J M Ferreri, M. Reni, A. Bolognesi, C. Verusio, E. Villa

Research output: Contribution to journalArticlepeer-review


A retrospective series of 13 immunocompetent patients with histological diagnosis of primary central nervous system lymphoma (PCNSL) is presented. The series was divided into Group A, 6 patients treated with radiotherapy alone, and Group B, 7 patients treated with chemotherapy and radiotherapy. Clinicopathological patterns were similar for the two groups. In Group A, 4 patients achieved complete remission after radiotherapy (45-59.4 Gy) but relapsed within 9 months and died within 21 months of diagnosis. 4 Group B patients received chemotherapy followed by radiotherapy, and three who received a methotrexate-containing regimen are alive and disease-free at 34, 42 and 45 months, while the fourth died after 11 months. The other 3 subjects in this group were treated with radiotherapy followed by chemotherapy, and died within 15 months of diagnosis. Although radiotherapy is the standard treatment, chemotherapy has potentially an important role in the management of PCNSL. The sequence of combined treatment could be crucial to improvement of outcome.

Original languageEnglish
Pages (from-to)2008-2012
Number of pages5
JournalEuropean Journal of Cancer
Issue number12
Publication statusPublished - 1995


  • blood-brain barrier
  • brain neoplasms
  • chemotherapy
  • combined modality therapy
  • non-Hodgkin's lymphomas
  • primary central nervous system lymphoma
  • radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Hematology


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