Combined treatment of advanced oropharyngeal cancer with external radiotherapy and three-step radioimmunotherapy

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Abstract

The prognosis of patients with locally advanced head and neck cancer remains grim due to poor locoregional tumour control. In the attempt to eradicate residual disease, various novel modalities have been tested, among which radioimmunotherapy (RIT) has shown some potential. We present a case of locally advanced oropharyneeal carcinoma successfully treated with a combination of various treatments including surgery, radio-chemotherapy and three-step RIT, with the avidin-biotin pretargeting system. A partial tumour response was achieved after surgery and radio-chemotherapy; persistent disease was documented at computed tomography (CT), ultrasound (US) and immunoscintigraphy (ISG) 10 weeks after the end of chemo-radiotherapy. The good correlation between the tracer localization in the scintigraphic images and residual mass visualized at CT suggested the application of three-step RIT using systemic administration of yttrium-90 (py) biotin. At present, 17 months after RIT, the patient is alive with no evidence of disease as documented by magnetic resonance imaging (MRI) and US. This is the first case of complete clinical remission of a head and neck carcinoma induced by combined treatment including pretargeted RIT with 90Y-biotin.

Original languageEnglish
Pages (from-to)1336-1339
Number of pages4
JournalEuropean Journal Of Nuclear Medicine
Volume25
Issue number9
DOIs
Publication statusPublished - 1998

Keywords

  • Head and neck carcinoma
  • Pretargeted radioimmunotherapy
  • Yttrium-90 biotin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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