Combined treatment of inoperable liver metastases from colorectal cancer.

Translated title of the contribution: Combined treatment of inoperable liver metastases from colorectal cancer

C. Milandri, F. Calzolari, E. Giampalma, A. Vagliasindi, A. Bertagni, L. Ridolfi, A. Passardi, R. Ridolfi, R. Golfieri, G. M. Verdecchia

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

AIMS: Liver resection improves survival in selected patients with colorectal liver metastases. However, the majority of patients with colorectal liver metastases have an inoperable oncological disease. The aim is to investigate whether intra-arterial infusion of chemotherapy, improves response to treatment and may convert a selected group of patients with irresectable liver metastases into an operable state. MATERIALS AND METHODS: Thirty-sex patients (pts) with inoperable hepatic metastases from colorectal cancer were treated with intra-arterial chemotherapy, by angiographic technique. All patients underwent a short 5-FU-based locoregional infusion and the 13 non pretreated patients also received systemic therapy. Evaluation of response was made by CT scan. RESULTS: Total cycles administered angiographically: 132 (range, 1-11). There were no complications associated with the angiographic procedure and no cases of > grade 2 toxicity. One heavily pretreated pt experienced moderate cholangitis and superficial gastric erosion. Thirty-one pts were assessable (20 pretreated and 11 not); there was 1 complete response (CR), 3 partial remissions (PR), 2 stabilizations (SD) among non-pretreated pts (6/11; CR + PR + SD = 55%) and 1 PR and 8 SD among pretreated pts (9/20; PR + SD = 45%). The remaining 16 pts progressed. Four pts became eligible for radical hepatic resection (1 refused surgery and 3 patients were operated on). There was no peri-operative deaths. Median survival of these 3 pts was 24, 28 and 39+ months. CONCLUSIONS: Our data, even if based on a relatively small case series, appear to confirm effective local disease control in this clinical setting. Regional chemotherapy used singly or in combination with systemic chemotherapy may convert a selected group of patients with irresectable liver metastases to an oncological disease that can benefit from surgical treatment.

Original languageItalian
Pages (from-to)112-114
Number of pages3
JournalTumori
Volume89
Issue number4 Suppl
Publication statusPublished - Jul 2003

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Colorectal Neoplasms
Neoplasm Metastasis
Liver
Therapeutics
Drug Therapy
Intra Arterial Infusions
Cholangitis
Survival
Fluorouracil
Stomach

ASJC Scopus subject areas

  • Cancer Research

Cite this

Milandri, C., Calzolari, F., Giampalma, E., Vagliasindi, A., Bertagni, A., Ridolfi, L., ... Verdecchia, G. M. (2003). Combined treatment of inoperable liver metastases from colorectal cancer. Tumori, 89(4 Suppl), 112-114.

Combined treatment of inoperable liver metastases from colorectal cancer. / Milandri, C.; Calzolari, F.; Giampalma, E.; Vagliasindi, A.; Bertagni, A.; Ridolfi, L.; Passardi, A.; Ridolfi, R.; Golfieri, R.; Verdecchia, G. M.

In: Tumori, Vol. 89, No. 4 Suppl, 07.2003, p. 112-114.

Research output: Contribution to journalArticle

Milandri, C, Calzolari, F, Giampalma, E, Vagliasindi, A, Bertagni, A, Ridolfi, L, Passardi, A, Ridolfi, R, Golfieri, R & Verdecchia, GM 2003, 'Combined treatment of inoperable liver metastases from colorectal cancer.', Tumori, vol. 89, no. 4 Suppl, pp. 112-114.
Milandri C, Calzolari F, Giampalma E, Vagliasindi A, Bertagni A, Ridolfi L et al. Combined treatment of inoperable liver metastases from colorectal cancer. Tumori. 2003 Jul;89(4 Suppl):112-114.
Milandri, C. ; Calzolari, F. ; Giampalma, E. ; Vagliasindi, A. ; Bertagni, A. ; Ridolfi, L. ; Passardi, A. ; Ridolfi, R. ; Golfieri, R. ; Verdecchia, G. M. / Combined treatment of inoperable liver metastases from colorectal cancer. In: Tumori. 2003 ; Vol. 89, No. 4 Suppl. pp. 112-114.
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abstract = "AIMS: Liver resection improves survival in selected patients with colorectal liver metastases. However, the majority of patients with colorectal liver metastases have an inoperable oncological disease. The aim is to investigate whether intra-arterial infusion of chemotherapy, improves response to treatment and may convert a selected group of patients with irresectable liver metastases into an operable state. MATERIALS AND METHODS: Thirty-sex patients (pts) with inoperable hepatic metastases from colorectal cancer were treated with intra-arterial chemotherapy, by angiographic technique. All patients underwent a short 5-FU-based locoregional infusion and the 13 non pretreated patients also received systemic therapy. Evaluation of response was made by CT scan. RESULTS: Total cycles administered angiographically: 132 (range, 1-11). There were no complications associated with the angiographic procedure and no cases of > grade 2 toxicity. One heavily pretreated pt experienced moderate cholangitis and superficial gastric erosion. Thirty-one pts were assessable (20 pretreated and 11 not); there was 1 complete response (CR), 3 partial remissions (PR), 2 stabilizations (SD) among non-pretreated pts (6/11; CR + PR + SD = 55{\%}) and 1 PR and 8 SD among pretreated pts (9/20; PR + SD = 45{\%}). The remaining 16 pts progressed. Four pts became eligible for radical hepatic resection (1 refused surgery and 3 patients were operated on). There was no peri-operative deaths. Median survival of these 3 pts was 24, 28 and 39+ months. CONCLUSIONS: Our data, even if based on a relatively small case series, appear to confirm effective local disease control in this clinical setting. Regional chemotherapy used singly or in combination with systemic chemotherapy may convert a selected group of patients with irresectable liver metastases to an oncological disease that can benefit from surgical treatment.",
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AU - Ridolfi, L.

AU - Passardi, A.

AU - Ridolfi, R.

AU - Golfieri, R.

AU - Verdecchia, G. M.

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N2 - AIMS: Liver resection improves survival in selected patients with colorectal liver metastases. However, the majority of patients with colorectal liver metastases have an inoperable oncological disease. The aim is to investigate whether intra-arterial infusion of chemotherapy, improves response to treatment and may convert a selected group of patients with irresectable liver metastases into an operable state. MATERIALS AND METHODS: Thirty-sex patients (pts) with inoperable hepatic metastases from colorectal cancer were treated with intra-arterial chemotherapy, by angiographic technique. All patients underwent a short 5-FU-based locoregional infusion and the 13 non pretreated patients also received systemic therapy. Evaluation of response was made by CT scan. RESULTS: Total cycles administered angiographically: 132 (range, 1-11). There were no complications associated with the angiographic procedure and no cases of > grade 2 toxicity. One heavily pretreated pt experienced moderate cholangitis and superficial gastric erosion. Thirty-one pts were assessable (20 pretreated and 11 not); there was 1 complete response (CR), 3 partial remissions (PR), 2 stabilizations (SD) among non-pretreated pts (6/11; CR + PR + SD = 55%) and 1 PR and 8 SD among pretreated pts (9/20; PR + SD = 45%). The remaining 16 pts progressed. Four pts became eligible for radical hepatic resection (1 refused surgery and 3 patients were operated on). There was no peri-operative deaths. Median survival of these 3 pts was 24, 28 and 39+ months. CONCLUSIONS: Our data, even if based on a relatively small case series, appear to confirm effective local disease control in this clinical setting. Regional chemotherapy used singly or in combination with systemic chemotherapy may convert a selected group of patients with irresectable liver metastases to an oncological disease that can benefit from surgical treatment.

AB - AIMS: Liver resection improves survival in selected patients with colorectal liver metastases. However, the majority of patients with colorectal liver metastases have an inoperable oncological disease. The aim is to investigate whether intra-arterial infusion of chemotherapy, improves response to treatment and may convert a selected group of patients with irresectable liver metastases into an operable state. MATERIALS AND METHODS: Thirty-sex patients (pts) with inoperable hepatic metastases from colorectal cancer were treated with intra-arterial chemotherapy, by angiographic technique. All patients underwent a short 5-FU-based locoregional infusion and the 13 non pretreated patients also received systemic therapy. Evaluation of response was made by CT scan. RESULTS: Total cycles administered angiographically: 132 (range, 1-11). There were no complications associated with the angiographic procedure and no cases of > grade 2 toxicity. One heavily pretreated pt experienced moderate cholangitis and superficial gastric erosion. Thirty-one pts were assessable (20 pretreated and 11 not); there was 1 complete response (CR), 3 partial remissions (PR), 2 stabilizations (SD) among non-pretreated pts (6/11; CR + PR + SD = 55%) and 1 PR and 8 SD among pretreated pts (9/20; PR + SD = 45%). The remaining 16 pts progressed. Four pts became eligible for radical hepatic resection (1 refused surgery and 3 patients were operated on). There was no peri-operative deaths. Median survival of these 3 pts was 24, 28 and 39+ months. CONCLUSIONS: Our data, even if based on a relatively small case series, appear to confirm effective local disease control in this clinical setting. Regional chemotherapy used singly or in combination with systemic chemotherapy may convert a selected group of patients with irresectable liver metastases to an oncological disease that can benefit from surgical treatment.

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