Combined treatment with steroids and azathioprine in IgA nephropathy: Design of a prospective randomised multicentre trial

Francesco Locatelli, Claudio Pozzi, Lucia Del Vecchio, Simeone Andrulli, Antonello Pani, Giambattista Fogazzi, Paolo Altieri, Claudio Ponticelli

Research output: Contribution to journalArticle

Abstract

Corticosteroids have had variable success in IgA nephropathy (IgAN). Our previous trial with a six-month course of steroids in IgAN patients showed they were effective in reducing the risk of renal function deterioration and proteinuria, but this effect seemed to decrease in the long term. This new randomised trial was designed to prospectively evaluate whether adding low- dose azathioprine to steroids improves long-term renal survival in adult biopsyproven IgAN patients with proteinuria ≥1 g/24h and plasma creatinine ≤2.0 mg/dl. The patients will be treated with steroids (methylprednisolone 1 g i.v. for three consecutive days at months 1, 3 and 5, plus oral prednisone 0.5 mg/kg every other day for six months) plus azathioprine 1.5 mg/kg/day for six months or steroids alone with the same schedule. Altogether a minimum of 346 patients should be enrolled within a four-year recruitment period. The planned duration of follow-up is five years.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
JournalJournal of Nephrology
Volume12
Issue number5
Publication statusPublished - Sep 1999

Keywords

  • Azathioprine
  • Chronic renal failure
  • IgA nephropathy
  • Progression
  • Proteinuria
  • Randomised trials
  • Steroids

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Locatelli, F., Pozzi, C., Del Vecchio, L., Andrulli, S., Pani, A., Fogazzi, G., Altieri, P., & Ponticelli, C. (1999). Combined treatment with steroids and azathioprine in IgA nephropathy: Design of a prospective randomised multicentre trial. Journal of Nephrology, 12(5), 308-311.