Combined use of high-sensitivity C-reactive protein and N-terminal pro-b-type natriuretic peptide for risk stratification of vascular surgery patients

Domenico Scrutinio, Gloria Guido, Piero Guida, Andrea Passantino, Domenico Angiletta, Daniela Santoro, Davide Marinazzo, Guido Regina

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background We sought to assess whether high-sensitivity C-reactive protein (hs-CRP) and pro-B-type natriuretic peptide (NT-proBNP) improve risk prediction when added to an established predictive tool and develop a point-based risk score. Methods Four hundred eleven vascular surgery patients were enrolled. The primary outcome was a composite of death, acute coronary syndromes, pulmonary edema within 30 days of surgery, and postoperative troponin-I elevation. The risk score was developed from a logistic regression model by using an integer-based scoring system. Results The rate of the primary outcome was 18%. Adding both hs-CRP and NT-proBNP to the Revised Cardiac Risk Index led to an increase in C statistic from 0.670 to 0.774. The net reclassification improvement was 0.210 (P = 0.004) and the integrated discrimination improvement was 0.112 (P = 0.0001). In the multivariable regression analysis used to develop the risk score, insulin therapy for diabetes (odds ratio [OR]: 2.8; P = 0.003), open surgery (OR: 1.95; P = 0.027), fibrinogen >377 mg/dL (OR: 2.83; P = 0.001), hs-CRP >3.2 mg/L (OR: 3.85; P <0.0001), and NT-proBNP >221 ng/L (OR: 4.05; P <0.0001) were associated with the primary outcome. There was no statistical evidence of overfit. The C index was 0.82 and the Hosmer-Lemeshow statistic was 1.61 (P = 0.0447). The observed and predicted rates of the primary outcome across quartiles of risk score were highly correlated. Conclusions Hs-CRP and NT-proBNP substantially improve risk prediction when added to an established predictive tool. The biochemical marker-based risk score may be useful for accurately risk-stratifying vascular surgery patients; nonetheless, further validation studies on external datasets are needed before it can be used in clinical practice.

Original languageEnglish
Pages (from-to)1522-1529
Number of pages8
JournalAnnals of Vascular Surgery
Volume28
Issue number6
DOIs
Publication statusPublished - 2014

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Natriuretic Peptides
C-Reactive Protein
Blood Vessels
Odds Ratio
Logistic Models
Troponin I
Validation Studies
Brain Natriuretic Peptide
Pulmonary Edema
Acute Coronary Syndrome
Ambulatory Surgical Procedures
Fibrinogen
Biomarkers
Regression Analysis
Insulin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Combined use of high-sensitivity C-reactive protein and N-terminal pro-b-type natriuretic peptide for risk stratification of vascular surgery patients. / Scrutinio, Domenico; Guido, Gloria; Guida, Piero; Passantino, Andrea; Angiletta, Domenico; Santoro, Daniela; Marinazzo, Davide; Regina, Guido.

In: Annals of Vascular Surgery, Vol. 28, No. 6, 2014, p. 1522-1529.

Research output: Contribution to journalArticle

Scrutinio, Domenico ; Guido, Gloria ; Guida, Piero ; Passantino, Andrea ; Angiletta, Domenico ; Santoro, Daniela ; Marinazzo, Davide ; Regina, Guido. / Combined use of high-sensitivity C-reactive protein and N-terminal pro-b-type natriuretic peptide for risk stratification of vascular surgery patients. In: Annals of Vascular Surgery. 2014 ; Vol. 28, No. 6. pp. 1522-1529.
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T1 - Combined use of high-sensitivity C-reactive protein and N-terminal pro-b-type natriuretic peptide for risk stratification of vascular surgery patients

AU - Scrutinio, Domenico

AU - Guido, Gloria

AU - Guida, Piero

AU - Passantino, Andrea

AU - Angiletta, Domenico

AU - Santoro, Daniela

AU - Marinazzo, Davide

AU - Regina, Guido

PY - 2014

Y1 - 2014

N2 - Background We sought to assess whether high-sensitivity C-reactive protein (hs-CRP) and pro-B-type natriuretic peptide (NT-proBNP) improve risk prediction when added to an established predictive tool and develop a point-based risk score. Methods Four hundred eleven vascular surgery patients were enrolled. The primary outcome was a composite of death, acute coronary syndromes, pulmonary edema within 30 days of surgery, and postoperative troponin-I elevation. The risk score was developed from a logistic regression model by using an integer-based scoring system. Results The rate of the primary outcome was 18%. Adding both hs-CRP and NT-proBNP to the Revised Cardiac Risk Index led to an increase in C statistic from 0.670 to 0.774. The net reclassification improvement was 0.210 (P = 0.004) and the integrated discrimination improvement was 0.112 (P = 0.0001). In the multivariable regression analysis used to develop the risk score, insulin therapy for diabetes (odds ratio [OR]: 2.8; P = 0.003), open surgery (OR: 1.95; P = 0.027), fibrinogen >377 mg/dL (OR: 2.83; P = 0.001), hs-CRP >3.2 mg/L (OR: 3.85; P <0.0001), and NT-proBNP >221 ng/L (OR: 4.05; P <0.0001) were associated with the primary outcome. There was no statistical evidence of overfit. The C index was 0.82 and the Hosmer-Lemeshow statistic was 1.61 (P = 0.0447). The observed and predicted rates of the primary outcome across quartiles of risk score were highly correlated. Conclusions Hs-CRP and NT-proBNP substantially improve risk prediction when added to an established predictive tool. The biochemical marker-based risk score may be useful for accurately risk-stratifying vascular surgery patients; nonetheless, further validation studies on external datasets are needed before it can be used in clinical practice.

AB - Background We sought to assess whether high-sensitivity C-reactive protein (hs-CRP) and pro-B-type natriuretic peptide (NT-proBNP) improve risk prediction when added to an established predictive tool and develop a point-based risk score. Methods Four hundred eleven vascular surgery patients were enrolled. The primary outcome was a composite of death, acute coronary syndromes, pulmonary edema within 30 days of surgery, and postoperative troponin-I elevation. The risk score was developed from a logistic regression model by using an integer-based scoring system. Results The rate of the primary outcome was 18%. Adding both hs-CRP and NT-proBNP to the Revised Cardiac Risk Index led to an increase in C statistic from 0.670 to 0.774. The net reclassification improvement was 0.210 (P = 0.004) and the integrated discrimination improvement was 0.112 (P = 0.0001). In the multivariable regression analysis used to develop the risk score, insulin therapy for diabetes (odds ratio [OR]: 2.8; P = 0.003), open surgery (OR: 1.95; P = 0.027), fibrinogen >377 mg/dL (OR: 2.83; P = 0.001), hs-CRP >3.2 mg/L (OR: 3.85; P <0.0001), and NT-proBNP >221 ng/L (OR: 4.05; P <0.0001) were associated with the primary outcome. There was no statistical evidence of overfit. The C index was 0.82 and the Hosmer-Lemeshow statistic was 1.61 (P = 0.0447). The observed and predicted rates of the primary outcome across quartiles of risk score were highly correlated. Conclusions Hs-CRP and NT-proBNP substantially improve risk prediction when added to an established predictive tool. The biochemical marker-based risk score may be useful for accurately risk-stratifying vascular surgery patients; nonetheless, further validation studies on external datasets are needed before it can be used in clinical practice.

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