Combined use of monopolar radiofrequency and transdermal drug delivery in the treatment of melasma

Norma Cameli, Elva Abril, Maria Mariano, Enzo Berardesca

Research output: Contribution to journalArticlepeer-review

Abstract

Melasma is a common acquired pigmentary disorder that has a considerable psychological impact on the patient. The recurrent and refractory nature of this condition makes it difficult for treatment. OBJECTIVE: We aim to evaluate the efficacy and safety of a combined system that simultaneously uses monopolar radiofrequency (RF) and transdermal drug delivery of phytocomplex containing 1% kojic acid in the treatment of melasma. MATERIALS AND METHODS Fifty: patients affected by melasma underwent 6 sessions of treatment at 1-week intervals. The outcome was evaluated before treatment (T0) and 1 month (T 1) and 6 months (T2) after treatment using the Melasma Area and Severity Index score, a Mexameter, and Visioface devices for digital and ultraviolet computerized image analysis of skin color. RESULTS: The image analysis showed that hyperpigmentation was significantly reduced at T 1 and T2 compared with baseline. Melasma Area and Severity Index score, the average melanin score, and the average erythema values showed a significant reduction. No side effects were observed or reported. CONCLUSION: This study describes the first report of improvement in melasma through the combined use of monopolar RF with transdermal delivery of depigmenting agents. This could be a safe, tolerable, and effective alternative tool for the treatment of melasma.

Original languageEnglish
Pages (from-to)748-755
Number of pages8
JournalDermatologic Surgery
Volume40
Issue number7
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Dermatology
  • Surgery

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