Combined use of mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis

Virginie Rozot, Amelio Patrizia, Selena Vigano, Jesica Mazza-Stalder, Elita Idrizi, Cheryl L. Day, Matthieu Perreau, Catherine Lazor-Blanchet, Khalid Ohmiti, Delia Goletti, Pierre Alexandre Bart, Willem Hanekom, Thomas J. Scriba, Laurent Nicod, Giuseppe Pantaleo, Alexandre Harari

Research output: Contribution to journalArticlepeer-review

Abstract

Immune-based assays are promising tools to help to formulate diagnosis of active tuberculosis. A multiparameter flow cytometry assay assessing T-cell responses specific to Mycobacterium tuberculosis and the combination of both CD4 and CD8 T-cell responses accurately discriminated between active tuberculosis and latent infection.

Original languageEnglish
Pages (from-to)432-437
Number of pages6
JournalClinical Infectious Diseases
Volume60
Issue number3
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • active tuberculosis disease
  • CD8 T cells
  • diagnosis
  • functional profile
  • latent Mtb infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

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