Abstract
Breast cancer is one of the most frequently diagnosed forms of cancer and different treatments are used to block its progression. However, it still represents a very common cause of death in women. Doxorubicin (Dox) is reported as an effective agent in breast cancer treatment nonetheless it induces many side-effects. For this reason, many laboratories are engaged in understanding how it is possible to decrease the drug concentration, considering that one of the possible solutions is to use drug synergy, combining it with natural substances. Recently we showed that a phenolic extract from flaxseed (FS) oil, named PEFSO, induced on MCF-7 cell line an increase of apoptosis with related modification of G0/G1 phase cell cycle, and the activation of signaling and pro-oxidant pathways. In this study we present data on the combined effect of Dox and PEFSO on two different breast cancer cell lines to define the conditions to use lower doses of this chemotherapeutic agent. We report the data relating to the ability of this mixture to induce cytotoxicity and apoptosis, cell cycle modification, mitochondrial membrane depolarization and activation of extrinsic and/or intrinsic apoptotic pathway.
| Original language | English |
|---|---|
| Pages (from-to) | 468-476 |
| Number of pages | 9 |
| Journal | International Journal of Oncology |
| Volume | 50 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 2017 |
Fingerprint
Keywords
- Apoptosis
- Breast cancer
- Cell cycle
- Phenolic extract
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Combining doxorubicin with a phenolic extract from flaxseed oil : Evaluation of the effect on two breast cancer cell lines. / Guerriero, Eliana; Sorice, Angela; Capone, Francesca; Stor Ti, Gabriella; Colonna, Giovanni; Ciliberto, Gennaro; Costantini, Susan.
In: International Journal of Oncology, Vol. 50, No. 2, 01.02.2017, p. 468-476.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Combining doxorubicin with a phenolic extract from flaxseed oil
T2 - Evaluation of the effect on two breast cancer cell lines
AU - Guerriero, Eliana
AU - Sorice, Angela
AU - Capone, Francesca
AU - Stor Ti, Gabriella
AU - Colonna, Giovanni
AU - Ciliberto, Gennaro
AU - Costantini, Susan
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Breast cancer is one of the most frequently diagnosed forms of cancer and different treatments are used to block its progression. However, it still represents a very common cause of death in women. Doxorubicin (Dox) is reported as an effective agent in breast cancer treatment nonetheless it induces many side-effects. For this reason, many laboratories are engaged in understanding how it is possible to decrease the drug concentration, considering that one of the possible solutions is to use drug synergy, combining it with natural substances. Recently we showed that a phenolic extract from flaxseed (FS) oil, named PEFSO, induced on MCF-7 cell line an increase of apoptosis with related modification of G0/G1 phase cell cycle, and the activation of signaling and pro-oxidant pathways. In this study we present data on the combined effect of Dox and PEFSO on two different breast cancer cell lines to define the conditions to use lower doses of this chemotherapeutic agent. We report the data relating to the ability of this mixture to induce cytotoxicity and apoptosis, cell cycle modification, mitochondrial membrane depolarization and activation of extrinsic and/or intrinsic apoptotic pathway.
AB - Breast cancer is one of the most frequently diagnosed forms of cancer and different treatments are used to block its progression. However, it still represents a very common cause of death in women. Doxorubicin (Dox) is reported as an effective agent in breast cancer treatment nonetheless it induces many side-effects. For this reason, many laboratories are engaged in understanding how it is possible to decrease the drug concentration, considering that one of the possible solutions is to use drug synergy, combining it with natural substances. Recently we showed that a phenolic extract from flaxseed (FS) oil, named PEFSO, induced on MCF-7 cell line an increase of apoptosis with related modification of G0/G1 phase cell cycle, and the activation of signaling and pro-oxidant pathways. In this study we present data on the combined effect of Dox and PEFSO on two different breast cancer cell lines to define the conditions to use lower doses of this chemotherapeutic agent. We report the data relating to the ability of this mixture to induce cytotoxicity and apoptosis, cell cycle modification, mitochondrial membrane depolarization and activation of extrinsic and/or intrinsic apoptotic pathway.
KW - Apoptosis
KW - Breast cancer
KW - Cell cycle
KW - Phenolic extract
UR - http://www.scopus.com/inward/record.url?scp=85013059127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013059127&partnerID=8YFLogxK
U2 - 10.3892/ijo.2017.3835
DO - 10.3892/ijo.2017.3835
M3 - Article
AN - SCOPUS:85013059127
VL - 50
SP - 468
EP - 476
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 2
ER -