Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines

Eliana Guerriero, Angela Sorice, Francesca Capone, Gabriella Stor Ti, Giovanni Colonna, Gennaro Ciliberto, Susan Costantini

Research output: Contribution to journalArticlepeer-review

Abstract

Breast cancer is one of the most frequently diagnosed forms of cancer and different treatments are used to block its progression. However, it still represents a very common cause of death in women. Doxorubicin (Dox) is reported as an effective agent in breast cancer treatment nonetheless it induces many side-effects. For this reason, many laboratories are engaged in understanding how it is possible to decrease the drug concentration, considering that one of the possible solutions is to use drug synergy, combining it with natural substances. Recently we showed that a phenolic extract from flaxseed (FS) oil, named PEFSO, induced on MCF-7 cell line an increase of apoptosis with related modification of G0/G1 phase cell cycle, and the activation of signaling and pro-oxidant pathways. In this study we present data on the combined effect of Dox and PEFSO on two different breast cancer cell lines to define the conditions to use lower doses of this chemotherapeutic agent. We report the data relating to the ability of this mixture to induce cytotoxicity and apoptosis, cell cycle modification, mitochondrial membrane depolarization and activation of extrinsic and/or intrinsic apoptotic pathway.

Original languageEnglish
Pages (from-to)468-476
Number of pages9
JournalInternational Journal of Oncology
Volume50
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Keywords

  • Apoptosis
  • Breast cancer
  • Cell cycle
  • Phenolic extract

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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