Combining radiotherapy with immunoscheckpoint inhibitors or CAR-T in renal cell carcinoma

Matteo Santoni; Daniel Y.C. Heng; Gaetano Aurilio; Andrea Iozzelli; Lucilla Servi; Andrea Fabiani; Massimo Giannini; Roberta Mazzucchelli; Alessia Cimadamore; Marina Scarpelli; Mohamed S. Zaghloul; Nicola Battelli; Rodolfo Montironi

doi:10.2174/1389450120666191017113051

Combining radiotherapy with immunoscheckpoint inhibitors or CAR-T in renal cell carcinoma

Matteo Santoni, Daniel Y.C. Heng, Gaetano Aurilio, Andrea Iozzelli, Lucilla Servi, Andrea Fabiani, Massimo Giannini, Roberta Mazzucchelli, Alessia Cimadamore, Marina Scarpelli, Mohamed S. Zaghloul, Nicola Battelli, Rodolfo Montironi

Research output: Contribution to journal › Article › peer-review

Abstract

Radiotherapy is considered a second life in Renal Cell Carcinoma (RCC) patients, mainly due to the introduction of immune checkpoint inhibitors, such as anti-Programmed-death (PD)-1, alone or in combination with anti-Cytotoxic T-Lymphocyte Antigen (CTLA)-4. Several trials are investigating the efficacy/safety of immune checkpoint inhibitors in sequential or combined strategies with radiotherapy. Chimeric Antigen Receptor (CAR)-T cells therapy as a promising approach in cancer patients has opened the way to novel possibilities of integrating therapies. The identification of biomarkers of tumor response to these combinations represents a challenge in RCC, together with the research for the best partner for immunotherapy in metastatic patients. In this review we illustrated preclinical/clinical data on the integration of radiotherapy with immunocheckpoint inhibitors or CART cells in RCC.

Original language	English
Pages (from-to)	416-423
Number of pages	8
Journal	Current Drug Targets
Volume	21
Issue number	4
DOIs	https://doi.org/10.2174/1389450120666191017113051
Publication status	Published - 2020

Keywords

CAR-T cells
Immunocheckpoint inhibitors
Immunotherapy
Programmed-death-1
Radiation therapy
Renal cell carcinoma

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Clinical Biochemistry

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Santoni, M., Heng, D. Y. C., Aurilio, G., Iozzelli, A., Servi, L., Fabiani, A., Giannini, M., Mazzucchelli, R., Cimadamore, A., Scarpelli, M., Zaghloul, M. S., Battelli, N., & Montironi, R. (2020). Combining radiotherapy with immunoscheckpoint inhibitors or CAR-T in renal cell carcinoma. Current Drug Targets, 21(4), 416-423. https://doi.org/10.2174/1389450120666191017113051

Combining radiotherapy with immunoscheckpoint inhibitors or CAR-T in renal cell carcinoma. / Santoni, Matteo; Heng, Daniel Y.C.; Aurilio, Gaetano; Iozzelli, Andrea; Servi, Lucilla; Fabiani, Andrea; Giannini, Massimo; Mazzucchelli, Roberta; Cimadamore, Alessia; Scarpelli, Marina; Zaghloul, Mohamed S.; Battelli, Nicola; Montironi, Rodolfo.

In: Current Drug Targets, Vol. 21, No. 4, 2020, p. 416-423.

Research output: Contribution to journal › Article › peer-review

Santoni, Matteo ; Heng, Daniel Y.C. ; Aurilio, Gaetano ; Iozzelli, Andrea ; Servi, Lucilla ; Fabiani, Andrea ; Giannini, Massimo ; Mazzucchelli, Roberta ; Cimadamore, Alessia ; Scarpelli, Marina ; Zaghloul, Mohamed S. ; Battelli, Nicola ; Montironi, Rodolfo. / Combining radiotherapy with immunoscheckpoint inhibitors or CAR-T in renal cell carcinoma. In: Current Drug Targets. 2020 ; Vol. 21, No. 4. pp. 416-423.

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abstract = "Radiotherapy is considered a second life in Renal Cell Carcinoma (RCC) patients, mainly due to the introduction of immune checkpoint inhibitors, such as anti-Programmed-death (PD)-1, alone or in combination with anti-Cytotoxic T-Lymphocyte Antigen (CTLA)-4. Several trials are investigating the efficacy/safety of immune checkpoint inhibitors in sequential or combined strategies with radiotherapy. Chimeric Antigen Receptor (CAR)-T cells therapy as a promising approach in cancer patients has opened the way to novel possibilities of integrating therapies. The identification of biomarkers of tumor response to these combinations represents a challenge in RCC, together with the research for the best partner for immunotherapy in metastatic patients. In this review we illustrated preclinical/clinical data on the integration of radiotherapy with immunocheckpoint inhibitors or CART cells in RCC.",

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Combining radiotherapy with immunoscheckpoint inhibitors or CAR-T in renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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