Combining TMS-EEG with transcranial direct current stimulation language treatment in aphasia

Susanna Cipollari, Domenica Veniero, Carmela Razzano, Carlo Caltagirone, Giacomo Koch, Paola Marangolo

Research output: Contribution to journalArticlepeer-review


Despite the fact that different studies have been performed using transcranial direct current stimulation (tDCS) in aphasia, so far, to what extent the stimulation of a cerebral region may affect the activity of anatomically connected regions remains unclear. The authors used a combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to explore brain areas' excitability modulation before and after active and sham tDCS. Six chronic aphasics underwent 3 weeks of language training coupled with tDCS over the right inferior frontal gyrus. To measure the changes induced by tDCS, TMS-EEG closed to the area stimulated with tDCS were calculated. A significant improvement after tDCS stimulation was found which was accompained by a modification of the EEG over the stimulated region.

Original languageEnglish
Pages (from-to)833-845
Number of pages13
JournalExpert Review of Neurotherapeutics
Issue number7
Publication statusPublished - Jul 1 2015


  • aphasia
  • brain stimulation
  • language rehabilitation
  • tDCS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)


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