Combining transcranial magnetic stimulation with electroencephalography to study human cortical excitability and effective connectivity

Mario Rosanova, Silvia Casarotto, Andrea Pigorini, Paola Canali, Adenauer G. Casali, Marcello Massimini

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Excitability and effective connectivity are key parameters of cortical circuits' functioning. Moreover, alterations of these parameters have been suggested to underlie neurologic and psychiatric conditions. Transcranial Magnetic Stimulation (TMS) combined with neuronavigation systems, electroencephalography (EEG), and reliable reconstruction of cortical generators allows to directly measure cortical excitability and effective connectivity, noninvasively and with the appropriate temporal resolution (milliseconds). Here, the main technical challenges that have to be dealt with to efficiently combine navigated TMS with EEG on human subjects and a step-by-step experimental procedure to perform a successful TMS/EEG measurement are presented. Finally, ad hoc analytical tools to extract indices of excitability and effective connectivity from TMS/EEG data are described together with examples of their application.

Original languageEnglish
Title of host publicationNeuromethods
Pages435-457
Number of pages23
Volume67
DOIs
Publication statusPublished - 2012

Publication series

NameNeuromethods
Volume67
ISSN (Print)08932336
ISSN (Electronic)19406045

Keywords

  • Cortical circuits
  • Neuronavigation
  • Noninvasive
  • Perturbation
  • TMS/EEG

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Psychiatry and Mental health

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