Comment: An ATG repeat in the 3′-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance

Antonio Pizzuti, Alessandra Argiolas, Rosa Di Paola, Roberto Baratta, Anna Rauseo, Maura Bozzali, Riccardo Vigneri, Bruno Dallapiccola, Vincenzo Trischitta, Lucia Frittitta

Research output: Contribution to journalArticlepeer-review

Abstract

Resistin is overexpressed in human adipose tissue of obese individuals and is likely to modulate insulin sensitivity. Resistin is, therefore, a candidate gene for insulin resistance. We searched for polymorphisms in the resistin gene by single strand conformation polymorphism and direct sequencing. An ATG triplet repeat in the 3′-untranslated region was identified and considered for association with insulin resistance. Three alleles were identified (allele 1:8 repeats, allele frequency, 0.3%; allele 2:7 repeats; allele frequency, 94.5%; allele 3:6 repeats; allele frequency, 5.2%). Two hundred and three unrelated white Caucasian nondiabetic subjects from Sicily and 456 from the Gargano area (center east coast of Italy) were analyzed. Among Sicilians, subjects carrying allele 3 had a lower fasting insulin and insulin resistance index (homeostasis model assessment of insulin resistance; P <0.001 for both) and glucose (P = 0.025) and insulin (P = 0.002) levels during the oral glucose tolerance test. In subjects from Gargano, those carrying allele 3 had lower fasting plasma glucose levels and serum triglycerides (P = 0.01 for both). When the 2 populations were analyzed together, subjects carrying allele 3 had lower fasting insulin levels (P <0.005), homeostasis model assessment of insulin resistance (P <0.005), and serum triglycerides (P = 0.01). In conclusion, our data suggest that subjects carrying allele 3 of the resistin gene are characterized by relatively high insulin sensitivity.

Original languageEnglish
Pages (from-to)4403-4406
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume87
Issue number9
DOIs
Publication statusPublished - Sep 2002

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Comment: An ATG repeat in the 3′-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance'. Together they form a unique fingerprint.

Cite this