Comment on: “Cell therapy for heart disease: Trial sequential analyses of two cochrane reviews”

G. Castellini, E. E. Nielsen, C. Gluud

Research output: Contribution to journalArticlepeer-review

Abstract

Trial Sequential Analysis (TSA) is a frequentist method to help researchers control the risks of random errors in meta-analyses.1 Fisher et al.2 used TSA on cell therapy for heart diseases. The present article discusses the usefulness of TSA and its dependence on the choice of the parameters for calculation of the required information size and the adjacent monitoring boundaries, and comments on the approach by Fisher et al.2.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalClinical Pharmacology and Therapeutics
Volume102
Issue number1
DOIs
Publication statusPublished - Jul 1 2017

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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