Commentary on the study of Roy et al. Amygdala Based Altered mir-128-3p in Conferring Susceptibility to Depression-like Behavior via Wnt Signalling

Gianluca Serafini, Alice Trabucco, Andrea Amerio, Andrea Aguglia, Mario Amore

Research output: Contribution to journalArticle

Abstract

The study of Roy and colleagues recently accepted for publication in International Journal of Neuropsychopharmacology is a very interesting report investigating the role of specific microRNAs (miRNAs) in vulnerability or resistance to major depressive disorder in a specific brain region (e.g., amygdala). MiRNAs may act as a mega-controller of gene expression being involved in the pathogenesis of major neuropsychiatric conditions. Interestingly, some of the altered miRNAs (e.g., hsa-miR-425-3p, miR-425, miR-674-3p, and miR-873-3p) identified in this study were found to be dysregulated even in existing studies, but several methodological issues may hamper the translation of basic research findings in clinical studies. MiRNAs are proposed as possible biomarkers of disease and treatment response to disentangle the biological complexity underlying major affective disorders. The main implications regarding the present findings are discussed.

Original languageEnglish
Pages (from-to)178-180
Number of pages3
JournalThe international journal of neuropsychopharmacology
Volume23
Issue number3
DOIs
Publication statusPublished - Apr 21 2020

Keywords

  • amygdala
  • major depressive disorder
  • miRNAs
  • resistance
  • vulnerability

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Commentary on the study of Roy et al. Amygdala Based Altered mir-128-3p in Conferring Susceptibility to Depression-like Behavior via Wnt Signalling'. Together they form a unique fingerprint.

  • Cite this