Common alterations in the serotonin transporter in platelets and lymphocytes of psychotic patients

Donatella Marazziti, B. Dell'Osso, S. Baroni, L. Betti, M. Catena, G. Giannaccini, A. Lucacchini, G. B. Cassano

Research output: Contribution to journalArticlepeer-review


Introduction: Given the controversial data concerning the role of the serotonin (5-HT) transporter in psychosis, our study was aimed to investigate this structure by means of the measurements of the re-uptake kinetics and of the protein density, in both platelets and lymphocytes of 25 out- and inpatients with different psychotic disorders. Methods: Diagnoses, according to DSM-IV criteria, were bipolar 1 disorders with mood incongruent psychotic features (14), mixed states (7) and schizophrenia (4). Twenty-five matched healthy subjects were also selected as the control group. Platelet and lymphocyte membranes were prepared according to standardized protocols, as were the [ 3H]5HT re-uptake and [3H]paroxetine ([3H]Par) binding. Results: The results of this study showed a decreased density of the [3H]Par binding sites coupled with a reduced velocity of [ 3H]5-HT re-uptake in both platelets and lymphocytes of psychotic patients, as compared with healthy control subjects. Conclusion: These findings would suggest a general abnormality of the 5-HT system in psychotic patients, probably not confined only to the brain.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
Issue number1
Publication statusPublished - Jan 2006

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)


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