TY - JOUR
T1 - Common and different neural markers in major depression and anxiety disorders
T2 - A pilot structural magnetic resonance imaging study
AU - Maggioni, Eleonora
AU - Giuseppe, Delvecchio
AU - Marika, Grottaroli
AU - Marco, Garzitto
AU - Sara, Piccin
AU - Carolina, Bonivento
AU - Marta, Maieron
AU - Serena, D'Agostini A.
AU - Giampaolo, P.
AU - Matteo, Balestrieri
AU - Paolo, Brambilla
PY - 2019/8/30
Y1 - 2019/8/30
N2 - Although anxiety and depression often co-occur and share some clinical features, it is still unclear if they are neurobiologically distinct or similar processes. In this study, we explored common and specific cortical morphology alterations in depression and anxiety disorders. Magnetic Resonance Imaging data were acquired from 13 Major Depressive Disorder (MDD), 11 Generalized Anxiety Disorder (GAD), 11 Panic Disorder (PD) patients and 21 healthy controls (HC). Regional cortical thickness, surface area (SA), volume and gyrification were measured and compared among groups. We found left orbitofrontal thinning in all patient groups, as well as disease-specific alterations. MDD showed volume deficits in left precentral gyrus compared to all groups, volume and area deficits in right fusiform gyrus compared to GAD and HC. GAD showed lower SA than MDD and PD in right superior parietal cortex, higher gyrification than HC in right frontal gyrus. PD showed higher gyrification in left superior parietal cortex when compared to MDD and higher SA in left postcentral gyrus compared to all groups. Our results suggest that clinical phenotypic similarities between major depression and anxiety disorders might rely on common prefrontal alterations. Frontotemporal and parietal abnormalities may represent unique biological signatures of depression and anxiety.
AB - Although anxiety and depression often co-occur and share some clinical features, it is still unclear if they are neurobiologically distinct or similar processes. In this study, we explored common and specific cortical morphology alterations in depression and anxiety disorders. Magnetic Resonance Imaging data were acquired from 13 Major Depressive Disorder (MDD), 11 Generalized Anxiety Disorder (GAD), 11 Panic Disorder (PD) patients and 21 healthy controls (HC). Regional cortical thickness, surface area (SA), volume and gyrification were measured and compared among groups. We found left orbitofrontal thinning in all patient groups, as well as disease-specific alterations. MDD showed volume deficits in left precentral gyrus compared to all groups, volume and area deficits in right fusiform gyrus compared to GAD and HC. GAD showed lower SA than MDD and PD in right superior parietal cortex, higher gyrification than HC in right frontal gyrus. PD showed higher gyrification in left superior parietal cortex when compared to MDD and higher SA in left postcentral gyrus compared to all groups. Our results suggest that clinical phenotypic similarities between major depression and anxiety disorders might rely on common prefrontal alterations. Frontotemporal and parietal abnormalities may represent unique biological signatures of depression and anxiety.
KW - Brain morphometry
KW - Generalized anxiety disorder
KW - Major depressive disorder
KW - MRI
KW - Panic disorder
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UR - http://www.scopus.com/inward/citedby.url?scp=85068252176&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2019.06.006
DO - 10.1016/j.pscychresns.2019.06.006
M3 - Article
AN - SCOPUS:85068252176
VL - 290
SP - 42
EP - 50
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
ER -