Common and different neural markers in major depression and anxiety disorders: A pilot structural magnetic resonance imaging study

Eleonora Maggioni, Delvecchio Giuseppe, Grottaroli Marika, Garzitto Marco, Piccin Sara, Bonivento Carolina, Maieron Marta, D'Agostini A. Serena, P. Giampaolo, Balestrieri Matteo, Brambilla Paolo

Research output: Contribution to journalArticle

Abstract

Although anxiety and depression often co-occur and share some clinical features, it is still unclear if they are neurobiologically distinct or similar processes. In this study, we explored common and specific cortical morphology alterations in depression and anxiety disorders. Magnetic Resonance Imaging data were acquired from 13 Major Depressive Disorder (MDD), 11 Generalized Anxiety Disorder (GAD), 11 Panic Disorder (PD) patients and 21 healthy controls (HC). Regional cortical thickness, surface area (SA), volume and gyrification were measured and compared among groups. We found left orbitofrontal thinning in all patient groups, as well as disease-specific alterations. MDD showed volume deficits in left precentral gyrus compared to all groups, volume and area deficits in right fusiform gyrus compared to GAD and HC. GAD showed lower SA than MDD and PD in right superior parietal cortex, higher gyrification than HC in right frontal gyrus. PD showed higher gyrification in left superior parietal cortex when compared to MDD and higher SA in left postcentral gyrus compared to all groups. Our results suggest that clinical phenotypic similarities between major depression and anxiety disorders might rely on common prefrontal alterations. Frontotemporal and parietal abnormalities may represent unique biological signatures of depression and anxiety.

Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume290
DOIs
Publication statusPublished - Aug 30 2019

Keywords

  • Brain morphometry
  • Generalized anxiety disorder
  • Major depressive disorder
  • MRI
  • Panic disorder

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Common and different neural markers in major depression and anxiety disorders: A pilot structural magnetic resonance imaging study'. Together they form a unique fingerprint.

  • Cite this

    Maggioni, E., Giuseppe, D., Marika, G., Marco, G., Sara, P., Carolina, B., Marta, M., Serena, DA. A., Giampaolo, P., Matteo, B., & Paolo, B. (2019). Common and different neural markers in major depression and anxiety disorders: A pilot structural magnetic resonance imaging study. Psychiatry Research - Neuroimaging, 290, 42-50. https://doi.org/10.1016/j.pscychresns.2019.06.006