Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types

Eric S. Martin, Giovanni Tonon, Raktim Sinha, Yonghong Xiao, Bin Feng, Alec C. Kimmelman, Alexei Protopopov, Elena Ivanova, Cameron Brennan, Kate Montgomery, Raju Kucherlapati, Gerald Bailey, Mark Redston, Lynda Chin, Ronald A. DePinho

Research output: Contribution to journalArticle

Abstract

Colorectal cancer (CRC) is a major cause of cancer morbidity and mortality, and elucidation of its underlying genetics has advanced diagnostic screening, early detection, and treatment. Because CRC genomes are characterized by numerous non-random chromosomal structural alterations, we sought to delimit regions of recurrent amplifications and deletions in a collection of 42 primary specimens and 37 tumor cell lines derived from chromosomal instability neoplasia and microsatellite instability neoplasia CRC subtypes and to compare the pattern of genomic aberrations in CRC with those in other cancers. Application of oligomer-based array-comparative genome hybridization and custom analytic tools identified 50 minimal common regions (MCRs) of copy number alterations, 28 amplifications, and 22 deletions. Fifteen were highly recurrent and focal (

Original languageEnglish
Pages (from-to)10736-10743
Number of pages8
JournalCancer Research
Volume67
Issue number22
DOIs
Publication statusPublished - Nov 15 2007

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Martin, E. S., Tonon, G., Sinha, R., Xiao, Y., Feng, B., Kimmelman, A. C., Protopopov, A., Ivanova, E., Brennan, C., Montgomery, K., Kucherlapati, R., Bailey, G., Redston, M., Chin, L., & DePinho, R. A. (2007). Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Research, 67(22), 10736-10743. https://doi.org/10.1158/0008-5472.CAN-07-2742