Common carotid arteries assessment in patients with Cushing's disease (CD) before and 1 year after successful cure: An echo-Doppler study

S. Spiezia, R. Pivonello, A. P. Assanti, A. Faggiano, G. Cerbone, R. Farina, A. Colao

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiovascular accidents represent the most important cause of death in CD. The aim of this study was to evaluate carotid arteries morphology and dynamics in patients with CD before and 1 year after disease cure. Twelve CD patients and 12 controls underwent echo-Doppler ultrasonography for measurement of intima-media thickness (IMT), systolic and diastolic media-media distance (SMM, DMM), lumen diameter (SLD, DLD) and peak velocity (SPV, DPV) and distensibility coefficient (DC) at both common carotid arteries. The presence of atherosclerotic plaques at level of common, internal or external carotid arteries was also evaluated. At study entry, CD patients had significantly increased IMT, and decreased SLD, DLD and DC compared to controls. Atherosclerotic plaques were found in 20% of patients and in none of the controls. One year after CD cure, a significant decrease of IMT and an increase of SLD, DLD and DC of common carotid arteries were found. A significant decrease of atherosclerotic plaques size was also observed in patients with documented plaques at study entry. In conclusion, patients with CD display a damage of carotid arteries, detectable by echo-Doppler ultrasonography and have an increased prevalence of premature atherosclerosis. The disease cure significantly improve the carotid arteries morphology and dynamics.

Original languageEnglish
JournalUltrasound in Medicine and Biology
Volume26
Issue numberSUPPL. 2
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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