Common Features of Patients With Autoimmune Atrophic Gastritis

Emanuela Miceli, Marco Vincenzo Lenti, Donatella Padula, Ombretta Luinetti, Claudia Vattiato, Claudio Maria Monti, Michele Di Stefano, Gino Roberto Corazza

Research output: Contribution to journalArticlepeer-review


Background & Aims: Autoimmune atrophic gastritis (AIG) is characterized by immune-mediated chronic inflammation of the gastric body and fundus, leading to hypo-achlorhydria and vitamin B12 deficiency. We analyzed the clinical features of AIG and sought to identify factors that might be used in diagnosis. Methods: We collected and analyzed clinical data from 99 consecutive patients (age, 59 ± 17 y) who were diagnosed with AIG, based on histologic factors and the presence of autoantibodies against gastric parietal cells. Results: Clinical factors that led to a diagnosis of AIG included hematologic findings related to vitamin B12 deficiency (n = 37), incidental histologic evidence in gastric biopsy specimens (n = 34), immune disorders (n = 18; 9 were celiac disease), neurologic symptoms (n = 6), and a family history of AIG (n = 4). Conclusions: Based on an analysis of 99 consecutive patients with AIG, this disorder is not solely a condition of the elderly. Other features to look for in making a diagnosis of AIG include vitamin B12 deficiency, histologic factors, and immune disorders.

Original languageEnglish
Pages (from-to)812-814
Number of pages3
JournalClinical Gastroenterology and Hepatology
Issue number7
Publication statusPublished - Jul 2012


  • Diagnostic factor
  • Gastric atrophy
  • Pernicious anemia
  • Stomach

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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