Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.

Mia M. Gaudet, Tomas Kirchhoff, Todd Green, Joseph Vijai, Joshua M. Korn, Candace Guiducci, Ayellet V. Segrè, Kate McGee, Lesley McGuffog, Christiana Kartsonaki, Jonathan Morrison, Sue Healey, Olga M. Sinilnikova, Dominique Stoppa-Lyonnet, Sylvie Mazoyer, Marion Gauthier-Villars, Hagay Sobol, Michel Longy, Marc Frenay, Study Collaborators GEMO Study Collaborators & 79 others Frans B L Hogervorst, Matti A. Rookus, J. Margriet Collée, Nicoline Hoogerbrugge, Kees E P van Roozendaal, Study Collaborators HEBON Study Collaborators, Marion Piedmonte, Wendy Rubinstein, Stacy Nerenstone, Linda Van Le, Stephanie V. Blank, Trinidad Caldés, Miguel de la Hoya, Heli Nevanlinna, Kristiina Aittomäki, Conxi Lazaro, Ignacio Blanco, Adalgeir Arason, Oskar T. Johannsson, Rosa B. Barkardottir, Peter Devilee, Olofunmilayo I. Olopade, Susan L. Neuhausen, Xianshu Wang, Zachary S. Fredericksen, Paolo Peterlongo, Siranoush Manoukian, Monica Barile, Alessandra Viel, Paolo Radice, Catherine M. Phelan, Steven Narod, Gad Rennert, Flavio Lejbkowicz, Anath Flugelman, Irene L. Andrulis, Gord Glendon, Hilmi Ozcelik, [No Value] OCGN, Amanda E. Toland, Marco Montagna, Emma D'Andrea, Eitan Friedman, Yael Laitman, Ake Borg, Mary Beattie, Susan J. Ramus, Susan M. Domchek, Katherine L. Nathanson, Tim Rebbeck, Amanda B. Spurdle, Xiaoqing Chen, Helene Holland, [No Value] kConFab, Esther M. John, John L. Hopper, Saundra S. Buys, Mary B. Daly, Melissa C. Southey, Mary Beth Terry, Nadine Tung, Thomas V. Overeem Hansen, Finn C. Nielsen, Mark H. Greene, Phuong L. Mai, Ana Osorio, Mercedes Durán, Raquel Andres, Javier Benítez, Jeffrey N. Weitzel, Judy Garber, Ute Hamann, [No Value] EMBRACE, Susan Peock, Margaret Cook, Clare Oliver, Debra Frost, Radka Platte, D. Gareth Evans

Research output: Contribution to journalArticle

Abstract

The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (

Original languageEnglish
JournalPLoS Genetics
Volume6
Issue number10
Publication statusPublished - 2010

Fingerprint

penetrance
Penetrance
breast neoplasms
mutation
cancer
Breast Neoplasms
Mutation
Genome-Wide Association Study
Uncertainty
Single Nucleotide Polymorphism
uncertainty
genome
neoplasms
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Gaudet, M. M., Kirchhoff, T., Green, T., Vijai, J., Korn, J. M., Guiducci, C., ... Evans, D. G. (2010). Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genetics, 6(10).

Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. / Gaudet, Mia M.; Kirchhoff, Tomas; Green, Todd; Vijai, Joseph; Korn, Joshua M.; Guiducci, Candace; Segrè, Ayellet V.; McGee, Kate; McGuffog, Lesley; Kartsonaki, Christiana; Morrison, Jonathan; Healey, Sue; Sinilnikova, Olga M.; Stoppa-Lyonnet, Dominique; Mazoyer, Sylvie; Gauthier-Villars, Marion; Sobol, Hagay; Longy, Michel; Frenay, Marc; GEMO Study Collaborators, Study Collaborators; Hogervorst, Frans B L; Rookus, Matti A.; Collée, J. Margriet; Hoogerbrugge, Nicoline; van Roozendaal, Kees E P; HEBON Study Collaborators, Study Collaborators; Piedmonte, Marion; Rubinstein, Wendy; Nerenstone, Stacy; Van Le, Linda; Blank, Stephanie V.; Caldés, Trinidad; de la Hoya, Miguel; Nevanlinna, Heli; Aittomäki, Kristiina; Lazaro, Conxi; Blanco, Ignacio; Arason, Adalgeir; Johannsson, Oskar T.; Barkardottir, Rosa B.; Devilee, Peter; Olopade, Olofunmilayo I.; Neuhausen, Susan L.; Wang, Xianshu; Fredericksen, Zachary S.; Peterlongo, Paolo; Manoukian, Siranoush; Barile, Monica; Viel, Alessandra; Radice, Paolo; Phelan, Catherine M.; Narod, Steven; Rennert, Gad; Lejbkowicz, Flavio; Flugelman, Anath; Andrulis, Irene L.; Glendon, Gord; Ozcelik, Hilmi; OCGN, [No Value]; Toland, Amanda E.; Montagna, Marco; D'Andrea, Emma; Friedman, Eitan; Laitman, Yael; Borg, Ake; Beattie, Mary; Ramus, Susan J.; Domchek, Susan M.; Nathanson, Katherine L.; Rebbeck, Tim; Spurdle, Amanda B.; Chen, Xiaoqing; Holland, Helene; kConFab, [No Value]; John, Esther M.; Hopper, John L.; Buys, Saundra S.; Daly, Mary B.; Southey, Melissa C.; Terry, Mary Beth; Tung, Nadine; Overeem Hansen, Thomas V.; Nielsen, Finn C.; Greene, Mark H.; Mai, Phuong L.; Osorio, Ana; Durán, Mercedes; Andres, Raquel; Benítez, Javier; Weitzel, Jeffrey N.; Garber, Judy; Hamann, Ute; EMBRACE, [No Value]; Peock, Susan; Cook, Margaret; Oliver, Clare; Frost, Debra; Platte, Radka; Evans, D. Gareth.

In: PLoS Genetics, Vol. 6, No. 10, 2010.

Research output: Contribution to journalArticle

Gaudet, MM, Kirchhoff, T, Green, T, Vijai, J, Korn, JM, Guiducci, C, Segrè, AV, McGee, K, McGuffog, L, Kartsonaki, C, Morrison, J, Healey, S, Sinilnikova, OM, Stoppa-Lyonnet, D, Mazoyer, S, Gauthier-Villars, M, Sobol, H, Longy, M, Frenay, M, GEMO Study Collaborators, SC, Hogervorst, FBL, Rookus, MA, Collée, JM, Hoogerbrugge, N, van Roozendaal, KEP, HEBON Study Collaborators, SC, Piedmonte, M, Rubinstein, W, Nerenstone, S, Van Le, L, Blank, SV, Caldés, T, de la Hoya, M, Nevanlinna, H, Aittomäki, K, Lazaro, C, Blanco, I, Arason, A, Johannsson, OT, Barkardottir, RB, Devilee, P, Olopade, OI, Neuhausen, SL, Wang, X, Fredericksen, ZS, Peterlongo, P, Manoukian, S, Barile, M, Viel, A, Radice, P, Phelan, CM, Narod, S, Rennert, G, Lejbkowicz, F, Flugelman, A, Andrulis, IL, Glendon, G, Ozcelik, H, OCGN, NV, Toland, AE, Montagna, M, D'Andrea, E, Friedman, E, Laitman, Y, Borg, A, Beattie, M, Ramus, SJ, Domchek, SM, Nathanson, KL, Rebbeck, T, Spurdle, AB, Chen, X, Holland, H, kConFab, NV, John, EM, Hopper, JL, Buys, SS, Daly, MB, Southey, MC, Terry, MB, Tung, N, Overeem Hansen, TV, Nielsen, FC, Greene, MH, Mai, PL, Osorio, A, Durán, M, Andres, R, Benítez, J, Weitzel, JN, Garber, J, Hamann, U, EMBRACE, NV, Peock, S, Cook, M, Oliver, C, Frost, D, Platte, R & Evans, DG 2010, 'Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.', PLoS Genetics, vol. 6, no. 10.
Gaudet MM, Kirchhoff T, Green T, Vijai J, Korn JM, Guiducci C et al. Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genetics. 2010;6(10).
Gaudet, Mia M. ; Kirchhoff, Tomas ; Green, Todd ; Vijai, Joseph ; Korn, Joshua M. ; Guiducci, Candace ; Segrè, Ayellet V. ; McGee, Kate ; McGuffog, Lesley ; Kartsonaki, Christiana ; Morrison, Jonathan ; Healey, Sue ; Sinilnikova, Olga M. ; Stoppa-Lyonnet, Dominique ; Mazoyer, Sylvie ; Gauthier-Villars, Marion ; Sobol, Hagay ; Longy, Michel ; Frenay, Marc ; GEMO Study Collaborators, Study Collaborators ; Hogervorst, Frans B L ; Rookus, Matti A. ; Collée, J. Margriet ; Hoogerbrugge, Nicoline ; van Roozendaal, Kees E P ; HEBON Study Collaborators, Study Collaborators ; Piedmonte, Marion ; Rubinstein, Wendy ; Nerenstone, Stacy ; Van Le, Linda ; Blank, Stephanie V. ; Caldés, Trinidad ; de la Hoya, Miguel ; Nevanlinna, Heli ; Aittomäki, Kristiina ; Lazaro, Conxi ; Blanco, Ignacio ; Arason, Adalgeir ; Johannsson, Oskar T. ; Barkardottir, Rosa B. ; Devilee, Peter ; Olopade, Olofunmilayo I. ; Neuhausen, Susan L. ; Wang, Xianshu ; Fredericksen, Zachary S. ; Peterlongo, Paolo ; Manoukian, Siranoush ; Barile, Monica ; Viel, Alessandra ; Radice, Paolo ; Phelan, Catherine M. ; Narod, Steven ; Rennert, Gad ; Lejbkowicz, Flavio ; Flugelman, Anath ; Andrulis, Irene L. ; Glendon, Gord ; Ozcelik, Hilmi ; OCGN, [No Value] ; Toland, Amanda E. ; Montagna, Marco ; D'Andrea, Emma ; Friedman, Eitan ; Laitman, Yael ; Borg, Ake ; Beattie, Mary ; Ramus, Susan J. ; Domchek, Susan M. ; Nathanson, Katherine L. ; Rebbeck, Tim ; Spurdle, Amanda B. ; Chen, Xiaoqing ; Holland, Helene ; kConFab, [No Value] ; John, Esther M. ; Hopper, John L. ; Buys, Saundra S. ; Daly, Mary B. ; Southey, Melissa C. ; Terry, Mary Beth ; Tung, Nadine ; Overeem Hansen, Thomas V. ; Nielsen, Finn C. ; Greene, Mark H. ; Mai, Phuong L. ; Osorio, Ana ; Durán, Mercedes ; Andres, Raquel ; Benítez, Javier ; Weitzel, Jeffrey N. ; Garber, Judy ; Hamann, Ute ; EMBRACE, [No Value] ; Peock, Susan ; Cook, Margaret ; Oliver, Clare ; Frost, Debra ; Platte, Radka ; Evans, D. Gareth. / Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. In: PLoS Genetics. 2010 ; Vol. 6, No. 10.
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T1 - Common genetic variants and modification of penetrance of BRCA2-associated breast cancer.

AU - Gaudet, Mia M.

AU - Kirchhoff, Tomas

AU - Green, Todd

AU - Vijai, Joseph

AU - Korn, Joshua M.

AU - Guiducci, Candace

AU - Segrè, Ayellet V.

AU - McGee, Kate

AU - McGuffog, Lesley

AU - Kartsonaki, Christiana

AU - Morrison, Jonathan

AU - Healey, Sue

AU - Sinilnikova, Olga M.

AU - Stoppa-Lyonnet, Dominique

AU - Mazoyer, Sylvie

AU - Gauthier-Villars, Marion

AU - Sobol, Hagay

AU - Longy, Michel

AU - Frenay, Marc

AU - GEMO Study Collaborators, Study Collaborators

AU - Hogervorst, Frans B L

AU - Rookus, Matti A.

AU - Collée, J. Margriet

AU - Hoogerbrugge, Nicoline

AU - van Roozendaal, Kees E P

AU - HEBON Study Collaborators, Study Collaborators

AU - Piedmonte, Marion

AU - Rubinstein, Wendy

AU - Nerenstone, Stacy

AU - Van Le, Linda

AU - Blank, Stephanie V.

AU - Caldés, Trinidad

AU - de la Hoya, Miguel

AU - Nevanlinna, Heli

AU - Aittomäki, Kristiina

AU - Lazaro, Conxi

AU - Blanco, Ignacio

AU - Arason, Adalgeir

AU - Johannsson, Oskar T.

AU - Barkardottir, Rosa B.

AU - Devilee, Peter

AU - Olopade, Olofunmilayo I.

AU - Neuhausen, Susan L.

AU - Wang, Xianshu

AU - Fredericksen, Zachary S.

AU - Peterlongo, Paolo

AU - Manoukian, Siranoush

AU - Barile, Monica

AU - Viel, Alessandra

AU - Radice, Paolo

AU - Phelan, Catherine M.

AU - Narod, Steven

AU - Rennert, Gad

AU - Lejbkowicz, Flavio

AU - Flugelman, Anath

AU - Andrulis, Irene L.

AU - Glendon, Gord

AU - Ozcelik, Hilmi

AU - OCGN, [No Value]

AU - Toland, Amanda E.

AU - Montagna, Marco

AU - D'Andrea, Emma

AU - Friedman, Eitan

AU - Laitman, Yael

AU - Borg, Ake

AU - Beattie, Mary

AU - Ramus, Susan J.

AU - Domchek, Susan M.

AU - Nathanson, Katherine L.

AU - Rebbeck, Tim

AU - Spurdle, Amanda B.

AU - Chen, Xiaoqing

AU - Holland, Helene

AU - kConFab, [No Value]

AU - John, Esther M.

AU - Hopper, John L.

AU - Buys, Saundra S.

AU - Daly, Mary B.

AU - Southey, Melissa C.

AU - Terry, Mary Beth

AU - Tung, Nadine

AU - Overeem Hansen, Thomas V.

AU - Nielsen, Finn C.

AU - Greene, Mark H.

AU - Mai, Phuong L.

AU - Osorio, Ana

AU - Durán, Mercedes

AU - Andres, Raquel

AU - Benítez, Javier

AU - Weitzel, Jeffrey N.

AU - Garber, Judy

AU - Hamann, Ute

AU - EMBRACE, [No Value]

AU - Peock, Susan

AU - Cook, Margaret

AU - Oliver, Clare

AU - Frost, Debra

AU - Platte, Radka

AU - Evans, D. Gareth

PY - 2010

Y1 - 2010

N2 - The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (

AB - The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers. In stage 1 using the Affymetrix 6.0 platform, 592,163 filtered SNPs genotyped were available on 899 young (

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M3 - Article

VL - 6

JO - PLoS Genetics

JF - PLoS Genetics

SN - 1553-7390

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