Abstract
Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.
| Original language | English |
|---|---|
| Article number | 58 |
| Journal | Breast Cancer Research |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Apr 22 2015 |
ASJC Scopus subject areas
- Cancer Research
- Oncology
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Common germline polymorphisms associated with breast cancer-specific survival. / Pirie, Ailith; Guo, Qi; Kraft, Peter; Canisius, Sander; Eccles, Diana M.; Rahman, Nazneen; Nevanlinna, Heli; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Dunning, Alison M.; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Dieter; Weltens, Caroline; Leunen, Karin; van Ongeval, Chantal; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A.; Olsen, Janet E.; Hallberg, Emily; Vachon, Celine; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Cornelissen, Sten; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Frederick; Le Marchand, Loic; Hopper, John L.; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C.; Cross, Simon S.; Reed, Malcolm W R; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J.; Hollestelle, Antoinette; Martens, John W M; van den Ouweland, Ans M W; Marme, Federick; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Brenner, Hermann; Butterbach, Katja; Holleczek, Bernd; Kataja, Vesa; Kosma, Veli Matti; Hartikainen, Jaana M.; Li, Jingmei; Brand, Judith S.; Humphreys, Keith; Devilee, Peter; Tollenaar, Robert A E M; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Ficarazzi, Filomena; Beckmann, Matthias W.; Hein, Alexander; Ekici, Arif B.; Balleine, Rosemary; Phillips, Kelly Anne; Benitez, Javier; Zamora, M. Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Siljie; Evans, D. Gareth; Abraham, Jean; Earl, Helena; Poole, Christopher J.; Hiller, Louise; Dunn, Janet A.; Bowden, Sarah; Yang, Rose; Campa, Daniele; Diver, W. Ryan; Gapstur, Susan M.; Gaudet, Mia M.; Hankinson, Susan; Hoover, Robert N.; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J.; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet Feung; Caldas, Carlos; Hunter, David J.; Lindstrom, Sara; Garcia-Closas, Montserrat; Couch, Fergus J.; Chenevix-Trench, Georgia; Mannermaa, Arto; Andrulis, Irene L.; Hall, Per; Chang-Claude, Jenny; Easton, Douglas F.; Bojesen, Stig E.; Cox, Angela; Fasching, Peter A.; Pharoah, Paul D P; Schmidt, Marjanka K.
In: Breast Cancer Research, Vol. 17, No. 1, 58, 22.04.2015.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Common germline polymorphisms associated with breast cancer-specific survival
AU - Pirie, Ailith
AU - Guo, Qi
AU - Kraft, Peter
AU - Canisius, Sander
AU - Eccles, Diana M.
AU - Rahman, Nazneen
AU - Nevanlinna, Heli
AU - Chen, Constance
AU - Khan, Sofia
AU - Tyrer, Jonathan
AU - Bolla, Manjeet K.
AU - Wang, Qin
AU - Dennis, Joe
AU - Michailidou, Kyriaki
AU - Lush, Michael
AU - Dunning, Alison M.
AU - Shah, Mitul
AU - Czene, Kamila
AU - Darabi, Hatef
AU - Eriksson, Mikael
AU - Lambrechts, Dieter
AU - Weltens, Caroline
AU - Leunen, Karin
AU - van Ongeval, Chantal
AU - Nordestgaard, Børge G.
AU - Nielsen, Sune F.
AU - Flyger, Henrik
AU - Rudolph, Anja
AU - Seibold, Petra
AU - Flesch-Janys, Dieter
AU - Blomqvist, Carl
AU - Aittomäki, Kristiina
AU - Fagerholm, Rainer
AU - Muranen, Taru A.
AU - Olsen, Janet E.
AU - Hallberg, Emily
AU - Vachon, Celine
AU - Knight, Julia A.
AU - Glendon, Gord
AU - Mulligan, Anna Marie
AU - Broeks, Annegien
AU - Cornelissen, Sten
AU - Haiman, Christopher A.
AU - Henderson, Brian E.
AU - Schumacher, Frederick
AU - Le Marchand, Loic
AU - Hopper, John L.
AU - Tsimiklis, Helen
AU - Apicella, Carmel
AU - Southey, Melissa C.
AU - Cross, Simon S.
AU - Reed, Malcolm W R
AU - Giles, Graham G.
AU - Milne, Roger L.
AU - McLean, Catriona
AU - Winqvist, Robert
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Grip, Mervi
AU - Hooning, Maartje J.
AU - Hollestelle, Antoinette
AU - Martens, John W M
AU - van den Ouweland, Ans M W
AU - Marme, Federick
AU - Schneeweiss, Andreas
AU - Yang, Rongxi
AU - Burwinkel, Barbara
AU - Figueroa, Jonine
AU - Chanock, Stephen J.
AU - Lissowska, Jolanta
AU - Sawyer, Elinor J.
AU - Tomlinson, Ian
AU - Kerin, Michael J.
AU - Miller, Nicola
AU - Brenner, Hermann
AU - Butterbach, Katja
AU - Holleczek, Bernd
AU - Kataja, Vesa
AU - Kosma, Veli Matti
AU - Hartikainen, Jaana M.
AU - Li, Jingmei
AU - Brand, Judith S.
AU - Humphreys, Keith
AU - Devilee, Peter
AU - Tollenaar, Robert A E M
AU - Seynaeve, Caroline
AU - Radice, Paolo
AU - Peterlongo, Paolo
AU - Manoukian, Siranoush
AU - Ficarazzi, Filomena
AU - Beckmann, Matthias W.
AU - Hein, Alexander
AU - Ekici, Arif B.
AU - Balleine, Rosemary
AU - Phillips, Kelly Anne
AU - Benitez, Javier
AU - Zamora, M. Pilar
AU - Perez, Jose Ignacio Arias
AU - Menéndez, Primitiva
AU - Jakubowska, Anna
AU - Lubinski, Jan
AU - Gronwald, Jacek
AU - Durda, Katarzyna
AU - Hamann, Ute
AU - Kabisch, Maria
AU - Ulmer, Hans Ulrich
AU - Rüdiger, Thomas
AU - Margolin, Sara
AU - Kristensen, Vessela
AU - Nord, Siljie
AU - Evans, D. Gareth
AU - Abraham, Jean
AU - Earl, Helena
AU - Poole, Christopher J.
AU - Hiller, Louise
AU - Dunn, Janet A.
AU - Bowden, Sarah
AU - Yang, Rose
AU - Campa, Daniele
AU - Diver, W. Ryan
AU - Gapstur, Susan M.
AU - Gaudet, Mia M.
AU - Hankinson, Susan
AU - Hoover, Robert N.
AU - Hüsing, Anika
AU - Kaaks, Rudolf
AU - Machiela, Mitchell J.
AU - Willett, Walter
AU - Barrdahl, Myrto
AU - Canzian, Federico
AU - Chin, Suet Feung
AU - Caldas, Carlos
AU - Hunter, David J.
AU - Lindstrom, Sara
AU - Garcia-Closas, Montserrat
AU - Couch, Fergus J.
AU - Chenevix-Trench, Georgia
AU - Mannermaa, Arto
AU - Andrulis, Irene L.
AU - Hall, Per
AU - Chang-Claude, Jenny
AU - Easton, Douglas F.
AU - Bojesen, Stig E.
AU - Cox, Angela
AU - Fasching, Peter A.
AU - Pharoah, Paul D P
AU - Schmidt, Marjanka K.
PY - 2015/4/22
Y1 - 2015/4/22
N2 - Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.
AB - Introduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value -8), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.
UR - http://www.scopus.com/inward/record.url?scp=84933050272&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84933050272&partnerID=8YFLogxK
U2 - 10.1186/s13058-015-0570-7
DO - 10.1186/s13058-015-0570-7
M3 - Article
AN - SCOPUS:84933050272
VL - 17
JO - Breast Cancer Research
JF - Breast Cancer Research
SN - 1465-5411
IS - 1
M1 - 58
ER -