Common variable immunodeficiency following Epstein-Barr virus infection.

G. Zuccaro, S. Della Bella, B. Polizzi, M. Vanoli, R. Scorza

Research output: Contribution to journalArticlepeer-review


The authors present a case of a patient who developed recurrent bacterial upper respiratory and pulmonary infections and marked hypogammaglobulinemia with a gradual decrease of serum IgG, IgA and IgM some months after acute Epstein-Barr virus infection. Test for identification of lymphocyte subpopulation showed increased CD8+ T-cells with a surface phenotype (CD8+, CD57+, HLA-DR+) characteristic of virus-induced, activated cytotoxic cells. Viral investigations showed a positive anti-EBNA titer, an IgG titer anti-VCA of 1:40, a negative IgG titer anti-EA and human immunodeficiency virus negativity. The authors conclude that these clinical features are indicative of possible common variable immunodeficiency following Epstein-Barr virus infection.

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalJournal of Clinical and Laboratory Immunology
Issue number1
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Immunology


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